Gourt > Health > Conditions and Diseases > Cancer > Musculoskeletal > Soft Tissue Sarcoma > Fibrosarcoma (1)
Fibrosarcoma (fibroblastic sarcoma) is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells.
Pathology
The tumor may present different degrees of differentiation: low grade (differentiated), intermediate malignancy and high malignancy (anaplastic). Depending on this differentiation, tumor cells may resemble mature fibroblasts (spindle-shaped), secreting collagen, with rare mitoses. These cells are arranged in short fascicles which split and merge, giving the appearance of "fish bone". Poorly differentiated tumors consist in more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing.
Fibrosarcoma in dogs and cats
Fibrosarcoma occurs most frequently in the mouth in dogs. The tumor is locally invasive, and recurs often following surgery. Radiation therapy and chemotherapy are also used in treatment. Fibrosarcoma is also a rare bone tumor in dogs. More on [ Fibrosarcoma ]
Boston Children's Hospital: My Child Has Fibrosarcoma - Definition of the disease, symptoms, diagnosis, staging, treatment, surgery options, chemotherapy, and prognosis.
eMedicine: Fibrosarcoma by Ian D Dickey, MD - Provides an introduction to the disease, studies, treatments, complications, pictures, and prognosis.
Meta Description: [ Fibrosarcoma - Fibrosarcoma is a tumor of mesenchymal cell origin that is composed of malignant fibroblasts in a collagen background. It can occur as a soft-tissue mass or as a primary or secondary bone tumor. Fibrosarcoma was diagnosed much more frequently in the past; it is now more reliably di... ]
The Doctors Doctor: Fibrosarcoma - Outline of the disease includes pathogenesis, characteristics, and links.
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