Gourt > Health > Conditions and Diseases > Cancer > Musculoskeletal > Bone > Osteosarcoma (2)
Osteosarcoma is the most common type of malignant bone cancer, accounting for 35% of primary bone malignancies. There is a preference for the metaphyseal region of tubular long bones. 50% of cases occur around the knee. It is a malignant connective (soft) tissue tumor whose neoplastic cells present osteoblastic differentiation and form tumoral bone.
Prevalence
It is the 6th leading cancer in children under age 15. Osteosarcoma affects 400 children under age 20 and 500 adults (most between the ages of 15-30) every year in the USA. Approximately 1/3 of the 900 will die each year, or about 300 a year. A second peak in incidence occurs in the elderly, usually associated with an underlying bone pathology such as Paget's disease, medullary infarct, or prior irradiation. Although about 90% of patients are able to have limb-salvage surgery, complications, such as infection, prosthetic loosening and non-union, or local tumor recurrence may cause the need for further surgery or amputation.
Pathology
The tumor may be localized at the end of the long bones. Most often it affects the upper end of tibia or humerus, of lower end of femur. The tumor is solid, hard, irregular ("fir-tree" or "sun-burst" appearance on X-ray examination) due to the tumor spicules of calcified bone radiating in right angles. Surrounding tissues are infiltrated. More on [ Osteosarcoma ]
RT @PeopleOnBikes: Please help raise awareness of Osteosarcoma & support kids fighting Cancer Join the @EricasWish5k10k event http://t.co/NLLUs7UP
Justin_fotog (J__) Sat, 04 Feb 2012 20:49:12 -0000
RT @PeopleOnBikes: Please help raise awareness of Osteosarcoma & support kids fighting Cancer Join the @EricasWish5k10k event http://t.co/NLLUs7UP
Please help raise awareness of Osteosarcoma & support kids fighting Cancer Join the @EricasWish5k10k event http://t.co/NLLUs7UP
PeopleOnBikes (People On Bikes) Sat, 04 Feb 2012 20:25:52 -0000
Please help raise awareness of Osteosarcoma & support kids fighting Cancer Join the @EricasWish5k10k event http://t.co/NLLUs7UP
CancerBACUP: Osteosarcoma - A childhood cancer that starts in the bone. Provides description of disease, causes, diagnosis, staging, grade, treatment, side effects, and references.
Meta Description: [ Information about osterosarcoma in children describing what it is, symptoms, diagnosis and treatment ]
Childhood Cancer: Osteosarcoma - Information for parents about the most common type of bone cancer. Includes risks, symtoms, diagnosis, various treatments, prognosis, and side effects.
Meta Description: [ Osteosarcoma is the most common type of bone cancer. Boys are more likely to have osteosarcoma than girls, and most cases of osteosarcoma involve the knee. ]
eMedicine: Osteosarcoma - Article by Charles T Mehlman focuses on high-grade intramedullary osteosarcoma, the most common type of bone cancer. Includes introduction, lab studies, histologic findings, treatment, and pictures.
Meta Description: [ Osteosarcoma - This article focuses on high-grade intramedullary osteosarcoma (also referred to as simply osteosarcoma), including its classic osteoblastic form and its fibroblastic and chondroblastic forms. Osteosarcoma is the most common malignant bone tumor (Vander Griend, 1996). It is thought... ]
NCI: Osteosarcoma/Bone Fibrous Histiocytoma - Patient and health professionalal information summaries about the treatment of osteosarcoma/malignant fibrous histiocytoma of bone. Includes description, treatment options, and references.
Meta Description: [ Expert-reviewed information summary about the treatment of osteosarcoma/malignant fibrous histiocytoma of bone. ]
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