Gourt > Health > Conditions and Diseases > Cancer > Centers (6)
- "Center" and "centre" redirect here. For other uses, see: Center (disambiguation).
In geometry, the centre or center of an object is a point in some sense in the middle of the object. If geometry is regarded as the study of isometry groups then the centre is a fixed point of the isometries.
Circles
The centre of a circle is the point equidistant from the points on the edge. Simlarly the centre of a sphere is the point equidistant from the points on the surface, and the centre of a line segment is the midpoint of the two ends. More on [ Centre (geometry) ]
Facilities :: Medicine
Oncology
Comparison of Pinnacle and SameSpots for Spot Quantification and Differential Expression in 2-Dimensional Gel Electrophoresis Studies
Jeffrey S. Morris Sun, 15 Feb 2009 04:27:12 -0800
2-DE is an important method for proteomics. Accurate spot detection and quantification on the resulting images is a challenging task, but must be done effectively for the technology to fulfill its potential. Traditional analytical methods have significant weaknesses, including spot mismatching and missing data. These problems require time-consuming manual editing to correct, which dramatically decreases throughput and compromises the objectivity and reproducibility of the analysis. To address this issue, we developed Pinnacle, a new method that markedly improves spot detection and quantification precision. Another new method implemented in Progenesis SameSpots, a commercial 2-DE analysis product, has also been touted as an improvement upon traditional approaches. In this study, we compared Pinnacle and SameSpots in spot detection and precision of quantification using two different dilution series, and evaluated the detection of differentially expressed proteins in two differential expression experiments. We found that SameSpots at times had problems with spot delineation, while Pinnacle did not. While both Pinnacle and SameSpots showed marked improvement in precision of spot quantifications over conventional methods, Pinnacle yielded spot quantifications with greater validity and reliability than SameSpots. Pinnacle detected more differentially expressed proteins than SameSpots, which may be a result of its increased precision and improved spot delineation.
Statistical Issues in Proteomic Research
Jeffrey S. Morris Thu, 31 Jul 2008 11:03:24 -0700
Microproteomics: Analysis of protein diversity in small samples
Howard B. Gutstein Fri, 13 Jun 2008 14:38:53 -0700
Proteomics, the large-scale study of protein expression in organisms, offers the potential to evaluate global changes in protein expression and their post-translational modifications that take place in response to normal or pathological stimuli. One challenge has been the requirement for substantial amounts of tissue in order to perform comprehensive proteomic characterization. In heterogeneous tissues, such as brain, this has limited the application of proteomic methodologies. Efforts to adapt standard methods of tissue sampling, protein extraction, arraying, and identification are reviewed, with an emphasis on those appropriate to smaller samples ranging in size from several microliters down to single cells. The effects of miniaturization on these analyses are highlighted using neuroscience-related examples, as are statistical issues unique to the high-dimensional datasets generated by proteomic experiments.
Pinnacle: A Fast, Automatic Method for Detecting and Quantifying Protein Spots in 2-Dimensional Gel Electrophoresis Data
Jeffrey S. Morris Tue, 04 Dec 2007 09:44:53 -0800
Motivation: One of the key limitations for proteomic studies using 2-dimensional gel electrophoresis (2DE) is the lack of rapid, robust, and reproducible methods for detecting, matching, and quantifying protein spots. The most commonly used approaches involve first detecting spots and drawing spot boundaries on individual gels, then matching spots across gels, and finally quantifying each spot by calculating normalized spot volumes. This approach is time con-suming, error-prone, and frequently requires extensive manual edit-ing, which can unintentionally introduce bias into the results.Results: We introduce a new method for spot detection and quanti-fication called Pinnacle that is automatic, quick, sensitive and spe-cific, and yields spot quantifications that are reliable and precise. This method incorporates a spot definition that is based on simple, straightforward criteria rather than complex arbitrary definitions, and results in no missing data. Using dilution series for validation, we demonstrate Pinnacle outperformed two well-established 2DE analysis packages, proving to be more accurate and yielding smaller CVs. More accurate quantifications may lead to increased power for detecting differentially expressed spots, an idea supported by the results of our group comparison experiment. Our fast, automatic analysis method makes it feasible to conduct very large 2DE-based proteomic studies that are adequately powered to find important protein expression differences.Availability: Matlab code to implement Pinnacle is available from the authors upon request for non-commercial use.
Laser capture sampling and analytical issues in proteomics
Howard Gutstein Tue, 04 Dec 2007 09:35:54 -0800
Proteomics holds the promise of evaluating global changes in protein expression and post-translational modificaiton in response to environmental stimuli. However, difficulties in achieving cellular anatomic resolution and extracting specific types of proteins from cells have limited the efficacy of these techniques. Laser capture microdissection has provided a solution to the problem of anatomical resolution in tissues. New extraction methodologies have expanded the range of proteins identified in subsequent analyses. This review will examine the application of laser capture microdissection to proteomic tissue sampling, and subsequent extraction of these samples for differential expression analysis. Statistical and other quantitative issues important for the analysis of the highly complex datasets generated are also reviewed.
Statistical contributions to proteomic research
Jeffrey S. Morris Wed, 04 Apr 2007 12:55:09 -0700
Proteomic profiling has the potential to impact the diagnosis, prognosis, and treatment of various diseases. A number of different proteomic technologies are available that allow us to look at many proteins at once, and all of them yield complex data that raise significant quantitative challenges. Inadequate attention to these quantitative issues can prevent these studies from achieving their desired goals, and can even lead to invalid results. In this chapter, we describe various ways the involvement of statisticians or other quantitative scientists in the study team can contribute to the success of proteomic research, and we outline some of the key statistical principles that should guide the experimental design and analysis of such studies.
South Cumbria Cancer Network - Provides information on available local services in this multi-site UK region. Includes links to other related resources.
Alegent Health: Head and Neck Cancer Center - Focus on treatment, reconstruction, rehabilitation and support. Multi-location facilities in Iowa and Nebraska.
American Institute for Cancer Ablation - Extension of the McCollough Institute in Golf Shores, Alabama that offers radiofrequency therapy.
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Arlington Cancer Center - Oncology services include diagnosis, treatment, research, education and support services. Located in the Dallas/Fort Worth, Texas area.
Bay Area Tumor Institute - Research, education and care are provided by this non-profit resource located in Oakland, California.
Meta Description: [ Bay Area Tumor Institute offers free programs in cancer research,
prevention, education, and consultation to San Francisco East Bay citizens. ]
Blount Memorial Hospital: Cancer Care - Offers services designed to meet the needs of the patient and family. Located in Maryville, Tennessee.
Meta Description: [ Blount Memorial Hospital offers comprehensive cancer services designed to meet the needs of both the patient and family. ]
Bon Secours St. Mary's Hospital: Cancer Care Center - Provides a range of services to patients and their families. Located in Richmond, Virginia.
Meta Description: [ The Bon Secours Richmond Health System support the healthcare need of central Virginia. Find out more about how we serve the community. ]
Burzynski Clinic - Offers clinic overview, FAQ and staff information. Located in Houston, Texas.
Meta Description: [ New innovative comprehensive gene therapy cancer treatment designed to treat the total person not just the cancer. Experience a gentle way to treat cancer today. ]
California Hematology Oncology Medical Group - Los Angeles center which offers traditional and complementary medicine.
Cancer Center of Iowa - Multi-location practice located in Des Moines, Iowa.
Cancer Center of Santa Barbara - Provides a full array of diagnostic and treatment services in addition to clinical trials, wellness programs, counseling and support groups.
Meta Description: [ Radiation Oncology, Hematology/Medical Oncology and Nuclear Medicine. Support services including: clinical research trials, wellness programs, counseling and cancer support groups. ]
Cancer Centers of Florida - Multi-center facilities that aim to offer treatment in comfortable surroundings. Serves the areas of Lake, Orange, Osceola, Polk and Seminole Counties.
Meta Description: [ At Cancer Centers of Florida, we take pride in providing our patients with treatment centers that are both comfortable and convenient.
Serving Lake, Orange, Osceola, Polk and Seminole Counties,
we have multiple centers that offer care to patients in their immediate community.
As part of U.... ]
Cancer Centers of North Carolina - Multi-site diagnostic and treatment facilities in and around Raleigh, North Carolina that provide ongoing support and care.
Meta Description: [ Cancer Centers of North Carolina has a range of advanced treatments, including radiation, chemotherapy, and access to clinical trials. ]
Cancer Centre for the Southern Interior - Diagnostic and treatment facility serving regions of British Columbia, Canada. Online information includes a local map, and previews the initial visit.
Meta Description: [ City of Hope is committed to Helping bCancer/b patients worldwide. ]
Cancer Treatment Centers of America - Group of affiliated facilities provides information about traditional and complementary treatment options. Location and contact details given.
Meta Description: [ Learn about a complete range of traditional and new innovative cancer treatment therapies designed to treat your mind, body, and soul, not just your cancer. Start fighting today. ]
CancerCare - Information about these medical facilities which provide care to the North Lancashire and South Lakeland areas in England.
Cedars-Sinai Oncology Program - Comprehensive inpatient and outpatient care for cancer patients from this Los Angeles area medical center.
Meta Description: [ Welcome to the Samuel Oschin Comprehensive Cancer Treatment Institute at Cedars-Sinai Medical Center. ]
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Charleston Cancer Center - Facility offers full array of diagnostic and treatment options including access to clinical trials. Located in South Carolina.
Meta Description: [ Charleston Cancer Center in Charleston South Carolina ]
Evansville Cancer Center - Provides information about radiation and medical oncology. The facility is located in Indiana.
Meta Description: [ Cancer resource site providing information on radiation and medical oncology, as well as our patient services, physicians, and links to other cancer related sites. ]
Fox Valley Hematology and Oncology - Multi-site oncology center based in Illinois. Provides information on services, physician profiles and contact details.
Geffen Cancer Center and Research Institute - Offers an approach which combines conventional therapies with complementary modalities. Located in Vero Beach, Florida.
Meta Description: [ Domain name renewal and affordable web hosting packages from Network Solutions ]
Health Alliance Cancer Services - Multidisciplinary approach to prevention, diagnosis and treatment. Offers information, support groups, news and resources. Centered in Cincinnati, Ohio.
Meta Description: [ Health Alliance cancer centers, staff and physicians offer a multidisciplinary approach to the prevention, diagnosis and treatment of cancer including everything from clinical trials to cancer information to support groups. ]
Hendrick Medical Center - Information about this Abilene, Texas cancer facility, as well as links to related news and articles.
Meta Description: [ Hendrick Medical Center in Abilene, Texas. Providing treatment for Cancer and Cancer. ]
Jay Monahan Center for Gastrointestinal Health - Screening, diagnosis, treatment and support for gastrointestinal cancers offered at the New York-Presbyterian Weill Cornell Medical Center.
Jewish Hospital: Lung Cancer Center - Louisville, Kentucky facility providing medical care for patients with tumors of the thoracic region.
Meta Description: [ Jewish Hospital HealthCare Services' regional network of more than 50 health care facilities provides complete health care services in Kentucky and southern Indiana including: hospitals, emergency air ambulance, assisted living, home health care, outpatient care, nursing home care, occupational h... ]
Kansas City Cancer Centers - Multi-location cancer diagnostic and treatment facility located in the greater Kansas City area.
Meta Description: [ Kansas City Cancer Center ]
Lewis Family Cancer Care Center - Provides details services, physicians and volunteers. Affiliated with the Pomona Valley Hospital Medical Center in Pomona, California.
Meta Description: [ Provides comprehensive cancer care and support in a community setting. ]
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London Regional Cancer Centre - Affiliate of the University of Western Ontario providing a full range of care including basic and translational research. Located in London, Ontario.
Louisiana Oncology Associates - Serving the needs of the mid-state area. Includes summaries of current cancer clinical trials and contact details.
Meta Description: [ Home of Louisiana Oncology Associates, your Acadiana cancer specialists. Creating Wellness at Home ]
Mary Bird Perkins Cancer Center - A multi-site community owned oncology facility located in Louisiana.
Memphis Cancer Center - Describes medical staff, treatments, clinical trials, locations and related topics. Locations in Memphis and Covington, Tennessee; Blytheville, Arkansas; and Oxford, Mississippi.
Meta Description: [ 2b interactive's mission is to work closely with you to develop and maintain a successful online venture through a well defined and strategic internet marketing campaign, including strategic planning, web site development and enhancement, technical services, interactivity, and online marketing. ]
Missouri Cancer Associates - Multi-site comprehensive diagnostic, treatment and support capability. Headquartered in Columbia, Missouri with other locations in the north and mid-state regions.
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Netherlands Cancer Institute: Head and Neck Cancer - Gives an overview of this Amsterdam-located center and its orientation. Includes information on rehabilitation after laryngectomy.
Meta Description: [ This site contains information on cancer in the head and neck and treatment in the netherlands Cancer Institute. ]
Northern Arizona Hematology and Oncology - Information about this Flagstaff, Arizona center. Discusses breast cancer care, clinical trials, alternative therapy, support and events.
Meta Description: [ We provide consulting services and therapy for patients with malignant diseases and hematologic disorders. We are a comprehensive cancer treatment center based in Flagstaff Arizona using the latest technology and pharmaceutical advancements. We strive to make advanced state of the art cancer care... ]
Northern Cancer Network UK - Information about diagnosis, treatment and support from this regional network of providers and hospitals in the north of England.
Northwest Arkansas Radiation Therapy Institute - NARTI is a multi-center organization that provides radiation therapy for cancer patients in northwest Arkansas regardless of ability to pay.
Meta Description: [ Northwest Arkansas Radiation Therapy Institute ]
Northwestern Ontario Regional Cancer Centre - Provides multidisciplinary oncology treatment for Canadians. Includes information regarding the programs, services and facility.
Meta Description: [ Thunder Bay Regional Health Sciences Centre ]
Oncology Associates of Bridgeport - Multi-location center in Trumball and Fairfield, Connecticut, that provides diagnostic and treatment services.
Meta Description: [ Oncology Associates of Bridgeport, PC ]
Oncology Center of Central Baltimore - Cancer treatment facility in Maryland. Provides location and contact details.
Meta Description: [ At the Oncology Center of Central Baltimore, Dr. Stanley D. Walker and Dr. Suman B. Rao offer knowledge that gets results, with more than 25 years of clinical and research experience between them. ]
Pelican Center - Offers surgery for cancers in the pelvic region. Based at the North Hampshire Hospital as affiliated with the private Hampshire Clinic and located in Basingstoke, England.
Meta Description: [ The Pelican Cancer Foundation is dedicated to world class precision surgery for treating the many common cancers that occur within the pelvic region. It has the highest cure rates for rectal cancer published anywhere in the world and the lowest percentage of permanent colostomies. ]
Penrose Cancer Center - Colorado Springs, Colorado facility which provides oncology care. Contact details given.
Meta Description: [ Penrose Cancer Center ]
Puget Sound Cancer Centers - Multi-site facilities in Washington state. Contact details given.
Meta Description: [ Edmonds and Seattle, physician information, cancer information, insurance information, clinical research, online maps, relevant news and legislation,Ó>
Rocky Mountain Cancer Centers - Multi-center locations throughout Colorado offering diagnosis, treatment, care and clinical trials.
Meta Description: [ RMCC is Colorado's largest and most comprehensive provider of cancer care with 20 locations and more than 50 physicians throughout the state. ]
Saint Mary's Cancer Center - Outlines institutional programs including screening, prevention, diagnosis, treatment and research. Located in Grand Rapids; serving West Michigan.
Sarah Cannon Cancer Center - Affiliated facilities in mid-Tennessee and southern Kentucky. Includes informational guides to chemotherapy and breast cancer.
Seattle Cancer Care Alliance - Network includes academic, research and pediatric facilities. Offers treatment information, links and research findings.
Meta Description: [ Learn about internationally renowned cancer treatment programs for, breast cancer, skin cancer, lung cancer, leukemia, prostate cancer, colon cancer, ovarian cancer, lymphoma, melanoma, cervical cancer, Stem Cell transplantation, liver cancer, pediatric cancers, testicular cancer, pancreatic canc... ]
Seattle Cancer Treatment and Wellness Center - Integrative care model: oncologists working with naturopathic and Chinese medicine practitioners. Contact details provided.
South Carolina Oncology Associates - Private cancer center located in Columbia, South Carolina. Includes information on the offered treatments, clinical trials, a FAQ and recommended resources.
Meta Description: [ South Carolina Oncology Associates (SCOA), the most comprehensive private cancer treatment center in South Carolina. ]
Stoke Mandeville Hospital - Cancer and blood-disorders center located in Aylesbury, England offers diagnosis, therapy, care and support. Includes information on the related Cancer Care and Haematology Fund.
Meta Description: [ The Cancer Care and Haematology Fund based at Stoke Mandeville Hospital provides patients with medical treatment, including chemotherapy, clinic review, treatment for blood disorders, including leukaemia and lymphoma, and complementary therapy. Patients and their families also receive emotional s... ]
Sutter Cancer Center - Offers diagnostic, treatment and support services. Located in Sacramento, California.
Meta Description: [ Information about Cancer Services at Sutter Health Sacramento Sierra Region. ]
Texas Cancer Institute - Treatment and research center at St. Luke's Episcopal Hospital in Houston. Provides patient information and a services overview.
The Center for Cancer Care and Research: St. Louis - Furnishes information about the functions and activities of this Missouri located facility.
Meta Description: [ The Center for Cancer Care and Research on the Web. ]
The Oncology Center: Orange, California - Gives overview cancer information as well as outlining diagnostic, treatment and support services.
Meta Description: [ The Oncology Center is Orange County's leading cancer center with all patient diagnostics, treatments and support services in one location. Comprehensive services include: imaging, surgery, chemotherapy, complementary medicine, social services, and volunteers. ]
The Saint Francis Care Regional Cancer Center - An outpatient treatment facility located in Hartford, Connecticut.
Meta Description: [ Saint Francis Hospital and Medical Center recognizes cancer as a major national health problem. The Cancer Clinical Program is a commitment to excellence within a cancer center frame-work, incorporating cancer prevention, detection, evaluation, treatment, rehabilitation, teaching and research.
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Thiruvananthapuram Regional Cancer Centre - A facility that serves the State of Kerala and adjoining areas of Tamil Nadu and Karnataka, India. Describes the diagnostic, research and treatment programs.
Thompson Cancer Survival Center - Offers state-of-the-art treatment, including clinical trials with investigational drugs for patients who do not respond to standard treatments. [Tennessee]
Meta Description: [ Thompson Cancer Survival Center is an outpatient facility located in Knoxville, TN offering state-of-the-art cancer treatment, including clinical trials with investigational drugs for patients who do not respond to standard treatments. ]
University of Iowa: Department of Radiation Oncology - Overview of cancer types, treatments, staff, post-graduate training and specialized programs.
US Oncology Cancer Centers - Affiliated facilities located in many regions of the United States. Gives physician profiles, photos, location and contact information.
Virginia Mason Medical Center: Cancer Institute - Seattle, Washington facility providing a wide array of oncology research, diagnostic, treatment and support services.
Meta Description: [ The file your browser requested could not be found on our servers. We have recently changed our web site and we may have moved around, renamed, or deleted certain files. ]
Virginia Oncology Associates Cancer Treatment Center - Multi-location center in the southeastern region of the state that specializes in diagnosis, treatment and care.
Meta Description: [ Virginia Oncology Associates is a private practice of physicians specializing in the diagnosis and treatment of cancer. ]
Western Washington Cancer Treatment Center - Diagnostic and treatment facility located in Olympia, Washington.
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