Medulloblastoma is the most common primary brain tumour in children, with a bimodal incidence at the ages of 4-8 years, then in the early 20s and accounts for ~20% of childhood brain tumors. Males out of female 3:2 or 3:1 in many cases. It is a rapidly growing embryonic tumor that arises in the posterior cerebellar vermis and neuroepithelial roof of the fourth ventricle.

=Pathogenesis= It is currently thought that medulloblastoma arises from cerebellar "stem cells" that have been prevented from dividing and differentiating into their normal cell types. This accounts from the varying histologic variants seen on biopsy. Rosette formation is highly characteristic of medulloblastoma and is seen in up to half of the cases.

Molecular genetics reveal a loss of genetic information on the distal part of chromosome 17, distal to the p53 gene, possibly accounting for the neoplastic transformation of the undifferentiated cerebellar cells. Medulloblastomas are also seen in Gorlin syndrome as well as Turcot syndrome. Another research has strongly implicated the JC virus, the virus that causes multifocal leukoencephalopathy.

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@drew my daughter @msgmessage is fighting brain cancer (medulloblastoma). Done with her chemo and radiation, ready to say FU TO CANCER!!
smitty767 (Mark Smith) Sat, 31 Oct 2009 03:19:07 -0000
@drew my daughter @msgmessage is fighting brain cancer (medulloblastoma). Done with her chemo and radiation, ready to say FU TO CANCER!!
@xsbaggageandco my nephew has Medulloblastoma. Sending prayers for this litte sweetheart!
Paigewh (Paige Hill) Sat, 31 Oct 2009 00:12:23 -0000
@xsbaggageandco my nephew has Medulloblastoma. Sending prayers for this litte sweetheart!

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