Medulloblastoma is the most common primary brain tumour in children, with a bimodal incidence at the ages of 4-8 years, then in the early 20s and accounts for ~20% of childhood brain tumors. Males out of female 3:2 or 3:1 in many cases. It is a rapidly growing embryonic tumor that arises in the posterior cerebellar vermis and neuroepithelial roof of the fourth ventricle.

=Pathogenesis= It is currently thought that medulloblastoma arises from cerebellar "stem cells" that have been prevented from dividing and differentiating into their normal cell types. This accounts from the varying histologic variants seen on biopsy. Rosette formation is highly characteristic of medulloblastoma and is seen in up to half of the cases.

Molecular genetics reveal a loss of genetic information on the distal part of chromosome 17, distal to the p53 gene, possibly accounting for the neoplastic transformation of the undifferentiated cerebellar cells. Medulloblastomas are also seen in Gorlin syndrome as well as Turcot syndrome. Another research has strongly implicated the JC virus, the virus that causes multifocal leukoencephalopathy.

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Please go to this website and help this little boy www.strengthforjaxon.com he has anaplastic medulloblastoma every donation counts
tgonzales07 (missy gonzales) Sat, 21 Jan 2012 04:01:32 -0000
Please go to this website and help this little boy www.strengthforjaxon.com he has anaplastic medulloblastoma every donation counts
Please #pray for Bree #medulloblastoma http://t.co/sSMX3QR4
CPREzra823 (Child of God) Sat, 21 Jan 2012 00:58:14 -0000
Please #pray for Bree #medulloblastoma http://t.co/sSMX3QR4
Please #pray for Bree who is fighting Medulloblastoma and had bad scan results http://t.co/QAkFaead
CPREzra823 (Child of God) Fri, 20 Jan 2012 18: Subscribe to Medulloblastoma RSS feed