Gourt > Health > Conditions and Diseases > Blood Disorders > von Willebrand
Von Willebrand's disease (vWD) is the most common hereditary coagulation abnormality described in humans. It arises from a qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for platelet adhesion. It is known to affect humans and, in veterinary medicine, dogs.
Symptoms
The various types of vWD present with varying degrees of bleeding tendency. Severe internal or joint bleeding is rare (only in type 3 vWD); bruising, nosebleeds, heavy menstrual periods (in women) and blood loss during childbirth (rare) may occur.
Diagnosis
When suspected, blood plasma of a patient needs to be investigated for quantitative and qualitative deficiencies of vWF. This is achieved by measuring the amount of vWF in a vWF antigen assay and the functionallity of vWF with a glycoprotein (GP)Ib binding assay, a collagen binding assay or, a ristocetin cofactor (RiCof) activity assay. Factor VIII levels are also performed as factor VIII is bound to vWF which protects the factor VIII from rapid break down within the blood. Deficiency of vWF can therefore lead to a reduction in Factor VIII levels. Normal levels do not exclude all forms of vWD: particularly type 2 which may only be revealed by investigating platelet interaction with subendothelium under flow (PAF), a highly specialized coagulation study not routinely performed in most medical laboratories. A platelet aggregation assay will show an abnormal response to ristocetin with normal responses to the other agonists used. A platelet function assay (PFA) will give an abnormal collagen/adrenaline closure time but a normal collagen/ADP time. Type 2N can only be diagnosed by performing a "factor VIII binding" assay. Detection of vWD is complicated by vWF being an acute phase reactant with levels rising in infection, pregnancy and stress. More on [ Von Willebrand disease ]
Where does von Willebrand factor come from? http://www.pathologystudent.com/?p=1792
PathStudent (Pathology Student) Wed, 04 Nov 2009 16:04:45 -0000
Where does von Willebrand factor come from? http://www.pathologystudent.com/?p=1792
Doença de von Willebrand: http://bit.ly/1RpHc5
_Detinha_ (Detinha Albuquerque) Wed, 04 Nov 2009 11:48:45 -0000
Doença de von Willebrand: http://bit.ly/1RpHc5
I've not only had one stabbed I've given them a serious blood clotting condition know as Von Willebrand Disease.
Amia196 (Amy Sammons) Mon, 02 Nov 2009 17:09:22 -0000
I've not only had one stabbed I've given them a serious blood clotting condition know as Von Willebrand Disease.
Anyone know anything about Von Willebrand's disease or 1p36 monomy?
EvaRobinson77 (Geneva Robinson) Sat, 31 Oct 2009 04:27:33 -0000
Anyone know anything about Von Willebrand's disease or 1p36 monomy?
MedPro Rx, Inc. Releases Podcast On Von Willebrand Disease - http://bit.ly/3rCIVJ
MMInews (MMI Public Relations) Thu, 29 Oct 2009 15:32:22 -0000
MedPro Rx, Inc. Releases Podcast On Von Willebrand Disease - http://bit.ly/3rCIVJ
MedPro Rx, Inc. Releases Podcast On Von Willebrand Disease http://tinyurl.com/yktavy8
CarolinaBusines (Carolina Business) Thu, 29 Oct 2009 13:34:37 -0000
MedPro Rx, Inc. Releases Podcast On Von Willebrand Disease http://tinyurl.com/yktavy8
All About Bleeding - A resource for education, guidance and support for people who have or suspect they have von Willebrand disease. Offers personalized tools, information resources, and community support.
Meta Description: [ Your personal resource for education, guidance and support for people who have or suspect they have von Willebrand disease. ]
Canadian Hemophilia Society - Offers information about Von Willebrand disease. Includes the types, the symptoms, treatment, and heredity.
Matt Klimshuk - von Willebrand's Disease - Information on von Willebrand's Disease and links to von Willebrand's and Hemophilia sites.
Obgynnet's von Willebrand Disease Information Sheet - Specific information on how this hereditary disease impacts women.
The Other Bleeding Disorder - Information on the three types of von Willebrand Disease as well as treatments.
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