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Neutropenia is a hematological disorder characterized by an abnormally low number of neutrophil granulocytes (a type of white blood cell). Neutrophils usually make up 50-70% of circulating white blood cells and serve as the primary defence against infections by destroying bacteria in the blood. Hence, patients with neutropenia are more susceptible to bacterial infections and without prompt medical attention, the condition may become life-threatening. Neutropenia can be acute or chronic depending on the duration of the illness. A patient has chronic neutropenia if the condition lasts for greater than 3 months. It is sometimes used interchangeably with the term leukopenia. However, neutropenia is more properly considered a subset of leukopenia as a whole.

Classification


There are four general guidelines used to classify the severity of neutropenia based on the absolute neutrophil count (ANC) measured in cells per microlitre of blood:
  • Neutropenia (ANC < 2000) — slight risk of infection
  • Mild Neutropenia (1000 < ANC < 1500) — minimal risk of infection
  • Moderate Neutropenia (500 < ANC < 1000) — moderate risk of infection
  • Severe Neutropenia (ANC < 500) — severe risk of infection.

Types


Severe chronic neutropenia may be present at birth (congenital neutropenia) or may occur at any stage in life (acquired neutropenia). There are four main types of severe chronic neutropenia:

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Incidence, Risk Factors, and Impact of Severe Neutropenia After Hyperthermic Intraperitoneal Mitomycin C: http://bit.ly/76OWFj
PMPCURE (PMP Research Found.) Mon, 21 Dec 2009 14:42:59 -0000
Incidence, Risk Factors, and Impact of Severe Neutropenia After Hyperthermic Intraperitoneal Mitomycin C: http://bit.ly/76OWFj
fdg-pet/ct in evaluation of persistent febrile neutropenia in cancer ppl http://bit.ly/7JeLP4
paidtrials (US Clinical Trials) Sat, 19 Dec 2009 06:46:46 -0000
fdg-pet/ct in evaluation of persistent febrile neutropenia in cancer ppl http://bit.ly/7JeLP4
fatigue & symptom burden in febrile neutropenia http://bit.ly/6Qm84U
localtrials (US Clinical Trials ) Sat, 19 Dec 2009 06:34:46 -0000
fatigue & symptom burden in febrile neutropenia http://bit.ly/6Qm84U
fatigue & symptom burden in febrile neutropenia http://bit.ly/6Qm84U
usclinicaltrial (US Clinical Trials) Sat, 19 Dec 2009 06:14:46 -0000
fatigue & symptom burden in febrile neutropenia http://bit.ly/6Qm84U
fatigue & symptom burden in febrile neutropenia http://bit.ly/6Qm84U
recruitingtrial (Recruiting Trials) Sat, 19 Dec 2009 05:18:41 -0000
fatigue & symptom burden in febrile neutropenia http://bit.ly/6Qm84U
acyclovir in preventing herpes simplex virus infection in ppl w/ neutropenia http://bit.ly/6e685T
goclinicaltrial (Clinical Trials) Thu, 17 Dec 2009 22:46:52 -0000
acyclovir in preventing herpes simplex virus infection in ppl w/ neutropenia http://bit.ly/6e685T

 
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MedicineNet: Neutropenia - Presents the causes, normal and abnormal white blood cell counts, and conditions associated with the disorder.

Neutropenia OnLine - Register, become a member and participate in a forum about this disorder.

Neutropenia Support Association - An extensive look at this disorder with information about the blood, the causes, the different types, symptoms and the treatment.
Meta Description: [ Increasing the understanding of neutropenia by providing information and support for care givers, patients and their families. ]

Severe Chronic Neutropenia International Registry - A disease registry which was established in Australia, Canada, the European Community and the United States in March, 1994. Information for patients and families and health care providers.

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