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Factor V Leiden (sometimes Factor VLeiden) is the name given to a variant of human factor V that causes a hypercoagulability disorder. In this disorder the Leiden variant of factor V, cannot be inactivated by activated protein C. Factor V Leiden is the most common hereditary hypercoagulability disorder amongst Eurasians. It is named after the city Leiden (The Netherlands), where it was first identified in 1994 by Prof R. Bertina et al.

Pathophysiology


In the normal person, factor V functions as a cofactor to allow factor X to generate the active form of an enzyme called thrombin. Thrombin in turn cleaves fibrinogen to fibrin, which polymerizes to form the dense meshwork that makes up the majority of a clot. Activated protein C (aPC) is a natural anticoagulant that acts to limit the extent of clotting by cleaving and degrading factor V.

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Factor Five Leiden Support - Support for sufferers of the Factor Five Leiden blood clotting disorder, an inherited blood condition discovered in 1995. History, glossary, and meeting information (Oregon).
Meta Description: [ Support group for people with the Factor Five Leiden condition. ]

Living with Factor V Leiden - Factor V Leiden is the most common hereditary blood coagulation disorder in the United States. It is present in 5% of the American population.
Meta Description: [ This site contains information for those living with Factor V Leiden -and other forms of thrombophilia ]

MASS Wholesalers - MASS Wholesalers, Home Decor, Gifts And More is a wholesale distributor of exotic home decor and imported gifts. No minimum orders. Drop shipping available.
Meta Description: [ Assorted scented bath and spa gift sets and gifts. Our wholesale gift sets make great gifts and resellers. Always at wholesale price. ]

404 The Role of Activated Protein C Resistance in the Pathogenesis of Venous Thrombosis - Center for Disease Control's page discussing the background of this disorder including study results, testing, and complications.
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500 University of Illinois Patient Resources - Description of factor V Leiden, its risks and treatment options. Also discusses the impact of other conditions on this disease.

Yahoo! Groups: Leiden Factor V Support - Message board and chat room for people diagnosed with the Factor V Leiden genetic disorder.
Meta Description: [ Leidenfactorvsupport: Leiden Factor V Support Group ]

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