Gourt > Health > Conditions and Diseases > Blood Disorders > Blood Coagulation > Factor V Leiden
Factor V Leiden (sometimes Factor VLeiden) is the name given to a variant of human factor V that causes a hypercoagulability disorder. In this disorder the Leiden variant of factor V, cannot be inactivated by activated protein C. Factor V Leiden is the most common hereditary hypercoagulability disorder amongst Eurasians. It is named after the city Leiden (The Netherlands), where it was first identified in 1994 by Prof R. Bertina et al.
Pathophysiology
In the normal person, factor V functions as a cofactor to allow factor X to generate the active form of an enzyme called thrombin. Thrombin in turn cleaves fibrinogen to fibrin, which polymerizes to form the dense meshwork that makes up the majority of a clot. Activated protein C (aPC) is a natural anticoagulant that acts to limit the extent of clotting by cleaving and degrading factor V.
More on [ Factor V Leiden ]
Thrombosis :: Vascular Disorders
Genetic Disorders
First Factor V Leiden, then prothrombin G20210A, now qualitative defect in Factor IX and thrombophilia. Amazing! See http://tr.im/palio600
Palio_Saratoga (Palio) Wed, 02 Dec 2009 16:29:57 -0000
First Factor V Leiden, then prothrombin G20210A, now qualitative defect in Factor IX and thrombophilia. Amazing! See http://tr.im/palio600
Factor Five Leiden Support - Support for sufferers of the Factor Five Leiden blood clotting disorder, an inherited blood condition discovered in 1995. History, glossary, and meeting information (Oregon).
Meta Description: [ Support group for people with the Factor Five Leiden condition. ]
Living with Factor V Leiden - Factor V Leiden is the most common hereditary blood coagulation disorder in the United States. It is present in 5% of the American population.
Meta Description: [ This site contains information for those living with Factor V Leiden -and other forms of thrombophilia ]
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The Role of Activated Protein C Resistance in the Pathogenesis of Venous Thrombosis - Center for Disease Control's page discussing the background of this disorder including study results, testing, and complications.
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University of Illinois Patient Resources - Description of factor V Leiden, its risks and treatment options. Also discusses the impact of other conditions on this disease.
Yahoo! Groups: Leiden Factor V Support - Message board and chat room for people diagnosed with the Factor V Leiden genetic disorder.
Meta Description: [ Leidenfactorvsupport: Leiden Factor V Support Group ]
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