Gourt > Health > Conditions and Diseases > Blood Disorders > Blood Coagulation (1)
The coagulation of blood is a complex process during which blood forms solid clots. It is an important part of haemostasis (the cessation of blood loss from a damaged vessel) whereby a damaged blood vessel wall is covered by a fibrin clot to stop hemorrhage and aid repair of the damaged vessel. Disorders in coagulation can lead to increased hemorrhage and/or thrombosis and embolism.
Coagulation is extremely similar in all mammals, with all mammals using a combined cellular and serine protease mechanism. The system in humans is the most extensively researched and therefore the best known. This article focuses on human blood coagulation.
In brief
In a normal individual, coagulation is initiated within 20 seconds after an injury occurs to the blood vessel damaging the endothelial cells. Platelets immediately form a haemostatic plug at the site of injury. This is called primary haemostasis. Secondary haemostasis then follows—plasma components called coagulation factors respond (in a complex cascade) to form fibrin strands which strengthen the platelet plug. Contrary to popular belief, coagulation from a cut on the skin is not initiated by air or drying out, but by platelets adhering to and activated by collagen in the blood vessel endothelium. The activated platelets then release the contents of their granules, these contain a variety of substances that stimulate further platelet activation and enhance the haemostatic process. More on [ Coagulation ]
Thrombosis :: Vascular Disorders
Grrr acid-base disorders and blood coagulation cascades be damned. Physiology can be a b*tch..a fascinating b*tch..but still a b*tch.
rutgherp (Rutgher Pruijm) Mon, 02 Nov 2009 18:17:29 -0000
Grrr acid-base disorders and blood coagulation cascades be damned. Physiology can be a b*tch..a fascinating b*tch..but still a b*tch.
RT @Doc__D: Hmmmmm coagulation cascade .. How blood clots ! Not bloodclaaat. Lol !â¢pun intended
el_CheHQ (Che Bowen) Mon, 26 Oct 2009 17:34:51 -0000
RT @Doc__D: Hmmmmm coagulation cascade .. How blood clots ! Not bloodclaaat. Lol !•pun intended
Hmmmmm coagulation cascade .. How blood clots ! Not bloodclaaat. Lol !
Doc__D (Dr. Daryl A. Daley) Mon, 26 Oct 2009 17:24:52 -0000
Hmmmmm coagulation cascade .. How blood clots ! Not bloodclaaat. Lol !
Substituted oxazolidinones and their use in the field of blood coagulation [5532255] http://bit.ly/4wPWj3
tweetalot (tweetalot) Mon, 26 Oct 2009 07:10:13 -0000
Substituted oxazolidinones and their use in the field of blood coagulation [5532255] http://bit.ly/4wPWj3
The Heparin drip is dripping dependably away, to slow down the coagulation of your blood situation. #latenighthospitalpoetry
BHumors (Brant Miller) Mon, 26 Oct 2009 06:26:35 -0000
The Heparin drip is dripping dependably away, to slow down the coagulation of your blood situation. #latenighthospitalpoetry
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Guidelines on Therapeutic Products to Treat Haemophilia and Other Hereditary Coagulation Disorders - Introduction and methods, manufacture of therapeutic coagulation factor concentrates, safety data on which recommendations are based, licensing status, therapeutic guidelines, clinical audit and a review of the guidelines.
Medline Plus: Congenital Protein C or S Deficiency - Brief information about these hypercoagulability disorders including causes, treatment, and prognosis.
Medline Plus: Factor V Deficiency - Provides brief information about this inherited bleeding disorder, which is similar to hemophilia. Includes causes, symptoms, and prognosis.
Medline Plus: Factor VII Deficiency - Brief information about this inherited bleeding disorder including causes, symptoms, and prognosis.
Medline Plus: Factor X Deficiency - Information about this inherited disorder that causes abnormal bleeding including causes, treatment, and prognosis.
Medline Plus: Factor XII Deficiency - Also known as Hageman factor, this is a congenital coagulation disorder that causes prolonged coagulation in a test tube but does not cause abnormal bleeding. Includes brief information.
Molecular Genetics of Blood Clotting - David Ginsburg, M.D: An article covering von Willebrand Factor, coagulation factor V, plasminogen activator inhibitor-1, primary pulmonary hypertension and bone marrow transplantation.
Protein S Deficiency and Thrombophilia - Information about these rare medical conditions, anticoagulant therapy, research and online forum.
Meta Description: [ Information about the rare medical condition of Protein S Deficiency and Thrombophilia, anticoagulant therapy, research and online forum. ]
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The Factor VIIa Source - Information about topics related to the pathophysiology, pharmacology, and clinical aspects of bleeding, coagulation, and hemostasis, including information about recombinant coagulation Factor VIIa.
Meta Description: [ FactorVIIa.com provides information about topics related to the pathophysiology, pharmacology, and clinical aspects of bleeding, coagulation, and hemostasis, including information about recombinant coagulation Factor VIIa (NovoSeven). ]
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UIUC Hematology Resource Page - Features diagrams and information about the various thrombophilic genetic markers, general information about clotting, glossary, and list of research sources.
Viewpoint Online: Coagulation - Features articles about blood coagulation disorders including activated protein C resistance, von Willbrand's disease, and hypercoagulability.
Viewpoint Online: Coagulation - Features articles about blood coagulation disorders including activated protein C resistance, von Willbrand's disease, and hypercoagulability.
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