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In medicine, infectious disease or communicable disease is disease caused by a biological agent such as by a virus, bacterium or parasite. This is contrasted to physical causes, such as burns or chemical ones such as through intoxication.

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Infectious diseases are the invasion of a host organism by a foreign replicator, generally microorganisms, often called microbes, that are invisible to the naked eye. Microbes that cause illness are also known as pathogens. The most common pathogens are various bacteria and viruses, though a number of other microorganisms, including some kinds of fungi and protozoa, also cause disease. Prions are borderline, and memes would not usually be considered in this scope. An infectious disease is termed contagious if it is easily transmitted from one person to another.

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