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CAM at the NIH - October 2008

Feature Stories Tips for Talking with Your Health Care ProviderAre you using—or thinking about using—complementary and alternative medicine (CAM)? If so, NCCAM provides some ideas on how to get a conversation started about CAM use when you talk to your health care providers. NCCAM Hosts Meditation WorkshopExperts from a wide range of fields and disciplines who share a common interest in meditation for health purposes met to assess current scientific knowledge and identify areas of opportunity for future research. Meet NACCAM Member Margery Gass, M.D.What are some things that women can do to stay healthy at midlife and beyond? NCCAM National Advisory Council member Margery Gass, M.D., a specialist in women's health, discusses this topic. Happiness and Systematic Mind-Body TrainingWhat do monks, meditation, and music have in common? Dr. Richard Davidson discusses his work on the science of happiness and on systematic training of the mind and body.

Tips for Talking With Your Health Care Providers About CAM

Like many Americans, you may be using or considering some form of complementary and alternative medicine (CAM). If so, it is a good idea to talk with your health care providers about your CAM use. This fact sheet explains why and offers some tips to help you get the conversation started. Key Points Tell your health care providers about all the complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care. Be proactive. Don't wait for your health care providers to ask about your CAM use. When you talk with your health care providers about CAM, make the most of the conversation. Bring a list of everything you use, keep a record of the information you receive, and ask questions if something is unclear.

Dietary Supplements Glucosamine and/or Chondroitin Fare No Better than Placebo in Slowing Structural Damage of Knee Osteoarthritis

The dietary supplements glucosamine and chondroitin sulfate, together or alone, appeared to fare no better than placebo in slowing loss of cartilage in osteoarthritis of the knee, researchers from the Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) team report in the October issue of Arthritis & Rheumatism. Interpreting the study results is complicated, however, because participants taking placebo had a smaller loss of cartilage, or joint space width, than predicted. Loss of cartilage, the slippery material that cushions the joints, is a hallmark of osteoarthritis and its loss is typically measured as a reduction in joint space width—the distance between the ends of bones in a joint as seen on an X-ray. "While these results are of interest, we cannot draw definitive conclusions about the utility of glucosamine or chondroitin in reducing joint space width loss, in part because the placebo group fared better than anticipated based on prior research results," said Josephine P. Briggs, M.D., director of the National Center for Complementary and Alternative Medicine, at the National Institutes of Health (NIH), one of the study's funders. "The results of the study provide interesting insights for future research."

Operation False Cure

The FTC today announced a new Web site about bogus cancer cures. The site — www.ftc.gov/curious — tells consumers how to spot and report bogus claims they see online, and urges people with cancer to talk to their treatment team about any products they'd like to try. The site features a video and includes a list of resources on cancer treatments from a variety of agencies within the federal government. Information is provided in English and Spanish. The Federal Trade Commission also announced 11 law enforcement actions challenging deceptive advertising of bogus cancer cures. The FTC charged the companies with making unsupported claims that their products cured or treated one or more types of cancer. In each case, the company is charged with violating the FTC Act, which bars deceptive claims. Some complaints allege that the companies also falsely touted clinical or scientific proof for their products.

New NIH Research Initiative to Test Treatments for Menopausal Symptoms

Clinical Trials to Target Hot Flashes, Night Sweats Women troubled by hot flashes and night sweats during the years around menopause want safe, effective treatment options. A new research initiative from the National Institutes of Health (NIH) will establish a multisite research network to conduct clinical trials of promising treatments for the most common symptoms of the menopausal transition. The initiative Menopause Strategies: Finding Lasting Answers for Symptoms and Health (MsFLASH) is led by the National Institute on Aging in collaboration with the National Center for Complementary and Alternative Medicine, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the Office of Research on Womens Health, all parts of the NIH. The MsFLASH network will be coordinated by principal investigators Andrea Z. LaCroix, Ph.D., and Garnet Anderson, Ph.D., both of the Fred Hutchinson Cancer Research Center in Seattle. The network centers will collectively receive approximately $4.4 million each year of the initiative, which is projected to run for five years. A Press Release from the National Institute on Aging

Message from the Director

As I've had the opportunity to meet with many of our stakeholders over the past 6 months, I have learned a lot. I've gained a greater appreciation of the complexities of studying CAM, the challenges to conducting rigorous research, and the need for setting clear priorities for the years ahead.

September Is Healthy Aging Month

The older population is growing rapidly, and the aging of the "baby boomers," born between 1946 and 1964 (and who begin turning age 65 in 2011), will accelerate this growth. Healthy Aging Month was designed to focus national attention on the positive aspects of growing older. Many older Americans use complementary and alternative medicine (CAM) to improve their health and maintain wellness. The National Center for Complementary and Alternative Medicine (NCCAM) conducts and supports research on many conditions associated with aging and provides information on how to be an informed consumer.

Paying for CAM Treatment

If you are using (or thinking about using), you may have financial questions about paying for treatment. This fact sheet answers some frequently asked questions on this topic. To find out more about any topic or resource that is mentioned. What are some questions to ask about paying for CAM treatment? Some questions to ask a CAM practitioner or his office staff are: What does the first appointment cost? What do followup appointments cost? How many appointments does someone with my condition typically need? Are there any additional costs (such as for tests, equipment, or supplements)? If you have a health insurance plan, some other questions are: Do you accept this insurance? What has your experience been with coverage by this insurance company for my condition? Do I file the claim forms, or do you take care of that? If it would be difficult for you to pay the full fee at each visit, you can ask: Could you arrange a payment plan over time? Do you offer a sliding-scale fee? (Sliding-scale fees are determined by people's income and ability to pay.)

Executive Summary of Meditation for Health Purposes Workshop

The purpose of the meeting was to articulate potential goals and directions for research on the mechanisms and efficacy of meditation practices for a variety of health concerns. Experts from a range of disciplines and with a wide range of involvement in the field of meditation research were asked to critically examine the current state of science on meditation for health, and to identify existing or potential intersections and contributions from their fields to further this area of science. This group developed a set of critical questions and approaches that could better inform future research in this area.

Reiki: An Introduction

Reiki is a healing practice that originated in Japan. Reiki practitioners place their hands lightly on or just above the person receiving treatment, with the goal of facilitating the person's own healing response. In the United States, Reiki is part of complementary and alternative medicine (CAM). This fact sheet provides a general overview of Reiki and suggests sources for additional information. People use Reiki to promote overall health and well-being. Reiki is also used by people who are seeking relief from disease-related symptoms and the side effects of conventional medical treatments. Reiki has historically been practiced as a form of self-care. Increasingly, it is also provided by health care professionals in a variety of clinical settings. People do not need a special background to learn how to perform Reiki. Currently, training and certification for Reiki practitioners are not formally regulated. Scientific research is under way to learn more about how Reiki may work, its possible effects on health, and diseases and conditions for which it may be helpful. Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Ayurvedic Medicine: An Introduction

Ayurvedic medicine (also called Ayurveda) is one of the world's oldest medical systems. It originated in India and has evolved there over thousands of years. In the United States, Ayurvedic medicine is considered complementary and alternative medicine (CAM)—more specifically, a CAM whole medical system. Many therapies used in Ayurvedic medicine are also used on their own as CAM—for example, herbs, massage, and specialized diets. This fact sheet provides a general overview of Ayurvedic medicine and suggests sources for additional information. Key Points The aim of Ayurvedic medicine is to integrate and balance the body, mind, and spirit. This is believed to help prevent illness and promote wellness. Ayurvedic medicine uses a variety of products and techniques to cleanse the body and restore balance. Some of these products may be harmful if used improperly or without the direction of a trained practitioner. For example, some herbs can cause side effects or interact with conventional medicines. Before using Ayurvedic treatment, ask about the practitioner's training and experience. Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

CAM at the NIH - July 2008

Feature Stories New Campaign Encourages Open Communication About CAM A new campaign from NCCAM, which offers free educational materials, is encouraging dialogue between patients and their health care providers about CAM use. A Walk in the Botanical Research Centers "Garden"Visit the NIH Botanical Research Centers "garden" to find out how Russian tarragon, prunella (self-heal), borage oil, and other botanical and dietary supplement ingredients are being examined to prevent and treat diseases and conditions. CAM and Fibromyalgia: At a GlanceFibromyalgia is a condition involving pain, "tender points" on the body, and fatigue. About nine out of 10 people with this condition use CAM. What is known from science about CAM's effectiveness for fibromyalgia?

CAM and Fibromyalgia: At a Glance

People with chronic health conditions such as fibromyalgia often turn to some form of complementary and alternative medicine (CAM)—a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine. This fact sheet provides basic information on fibromyalgia and "what the science says" about the effectiveness of CAM practices that many people with fibromyalgia use. If you are considering a CAM therapy for fibromyalgia, this information can help you talk to your health care provider about it.

CAM and Diabetes: A Focus on Dietary Supplements

Diabetes is a chronic condition affecting millions of Americans. Conventional medical treatments are available to control diabetes and its complications. However, some people also try complementary and alternative medicine (CAM) therapies, including dietary supplements. This fact sheet provides basic information on diabetes (with a focus on type 2), summarizes scientific research on the effectiveness and safety of selected supplements that people with diabetes sometimes use, and suggests sources for additional information. Key Points In general, there is not enough scientific evidence to prove that dietary supplements have substantial benefits for type 2 diabetes or its complications. It is very important not to replace conventional medical therapy for diabetes with an unproven CAM therapy. Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Grape Seed Extract May Help Prevent and Treat Alzheimer's

According to the National Institute on Aging (NIA), Alzheimer's disease affects nearly 4.5 million Americans and is the most common form of dementia in the elderly. Alzheimer's disease is an incurable disease with a slow progression beginning with mild memory loss and ending with severe brain damage and death. While no treatment is proven to stop Alzheimer's disease, some conventional drugs may limit symptoms for a short period of time in the early stages of the disease. Emerging research shows a correlation between red wine consumption and reduced risk of Alzheimer's disease-type cognitive decline. Authors of a new NCCAM-funded study in mice found that grape seed-derived polyphenolics—similar to that in red wine—significantly reduced Alzheimer's disease-type cognitive deterioration.

St. John's Wort Shows No Impact on the Symptoms of ADHD

According to the National Institute of Mental Health at NIH, Attention Deficit Hyperactivity Disorder (ADHD) affects 3 to 5 percent of children in the United States and it is one of the most common mental disorders that develop in children. NIMH states that children with ADHD have impaired functioning in multiple settings, including home, school, and in relationships with peers. Children with chronic conditions like ADHD are reported to have higher rates of complementary and alternative medicine use and may turn to dietary and herbal supplements such as St. John's wort. However, according to authors of a new NCCAM-funded study, St. John's wort does not appear to have an impact on the symptoms of ADHD in children and adolescents.

Time To Talk About CAM

The National Center for Complementary and Alternative Medicine (NCCAM), part of the National Institutes of Health (NIH), has launched Time to Talk, an educational campaign to encourage patients—particularly those age 50 or older—and their health care providers to openly discuss the use of complementary and alternative medicine (CAM). CAM is a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine, such as herbal supplements, meditation, naturopathy, and acupuncture. According to a national consumer survey conducted by NCCAM and AARP, almost two-thirds of people age 50 or older are using some form of CAM, yet less than one-third of these CAM users talk about it with their providers. The NCCAM/AARP survey revealed some reasons why this doctor-patient dialogue about CAM does not occur.

Message From The Director

I am now 4 months into this exciting and challenging new job as Director of NCCAM. In this short period, I have been given an excellent orientation to all areas of responsibility of the Center, guided by our terrific staff. I have also had the opportunity to speak with many CAM investigators, practitioners, and thought leaders, and some of our critics as well. I am learning a great deal from these various communities and perspectives. Clinicians have given me a sense of the promise that they see in the CAM approaches to health and wellness. Scientists have discussed the many challenges and knowledge gaps in conducting CAM research as well as the opportunities that are emerging from new research methods. NCCAM staff members have shared with me their expertise and experience in the complexities of oversight of our highly varied research portfolio. And CAM advocates who closely follow our progress have shared their perspective and hopes for NCCAM as well.

International Pharmaceuticals, Ltd. Issues a Voluntary Recall of all Viril-Ity-Power (VIP) Tabs

International Pharmaceuticals, Ltd. is conducting this recall after being informed by representatives of the Food and Drug Administration (FDA) that lab analysis by FDA of a sample from one lot of the product revealed that it contained a potentially harmful undeclared ingredient, hydroxyhomosildenafil. FDA asserts that this ingredient is an analog of sildenafil. Sildenafil is the active chemical ingredient of an FDA-approved drug used for Erectile Dysfunction in men to enhance sexual performance. The use of undeclared chemicals pose a threat to consumers because they may harmfully interact with nitrates found in some prescription drugs (such as nitroglycerin) and may lower blood pressure to dangerous levels. Consumers with diabetes, high blood pressure, high cholesterol, or heart disease often take such nitrates. VIP Tabs are sold in retail outlets nationwide and are packaged into 2-capsule blister packs and 8-capsule bottles.

Herbs at a Glance Book Now Available

Many people take herbal supplements to boost their immune systems, treat allergy symptoms, prevent a cold—all in an effort to be well and stay healthy. There are hundreds of herbal supplements available in the grocery store or pharmacy or for sale on the Internet. And, there are many claims about their health benefits. How can a consumer decide what's safe or effective? This booklet will give you a basic understanding of some of the most common herbs in popular dietary supplements—their historical uses, what they're used for now, the scientific evidence on their effectiveness, and side effects or cautions for you to consider. To manage your health, you need to be an informed consumer. Learn about herbal supplements and talk with your health care provider about everything you are doing to stay well.

Spinal Manipulation for Low-Back Pain

Low-back pain is a common condition that can be difficult to treat. Spinal manipulationThe application of controlled force to a joint, moving it beyond the normal range of motion in an effort to aid in restoring health. Manipulation may be performed as a part of other therapies or whole medical systems, including chiropractic medicine, massage, and naturopathy. is among the treatment options used by people with low-back pain in attempts to relieve pain and improve functioning. It is performed by chiropractors and other health care professionals such as physical therapists, osteopaths, and some conventional medical doctors. This fact sheet summarizes the current scientific knowledge about the effects of spinal manipulation on low-back pain.

Martin H. Goldrosen, Ph.D., Named Director of NCCAM's Division of Extramural Activities

Martin H. Goldrosen, Ph.D., was recently appointed director of the Division of Extramural Activities at the National Center for Complementary and Alternative Medicine, part of the National Institutes of Health. In announcing Dr. Goldrosen's appointment, Josephine P. Briggs, M.D., NCCAM Director, said "The Division of Extramural Activities is crucial to NCCAM's ability to review and fund high-quality research, as well as coordinate grant management and advisory committee activities. Dr. Goldrosen's experience and his extensive research background make him well-suited for this important work for NCCAM."

Yoga for Health: An Introduction

Yoga is a mind–body practice in complementary and alternative medicine (CAM) with origins in ancient Indian philosophy. The various styles of yoga that people use for health purposes typically combine physical postures, breathing techniques, and meditation or relaxation. This Backgrounder provides a general overview of yoga and suggests sources for more information. Yoga in its full form combines physical postures, breathing exercises, meditation, and a distinct philosophy. Yoga is intended to increase relaxation and balance the mind, body, and the spirit. Early written descriptions of yoga are in Sanskrit, the classical language of India. The word "yoga" comes from the Sanskrit word yuj, which means "yoke or union." It is believed that this describes the union between the mind and the body. The first known text, The Yoga Sutras, was written more than 2,000 years ago, although yoga may have been practiced as early as 5,000 years ago. Yoga was originally developed as a method of discipline and attitudes to help people reach spiritual enlightenment. The Sutras outline eight limbs or foundations of yoga practice that serve as spiritual guidelines.

NIH Yoga Week is May 19–23, 2008

This 5-day series of events will highlight the science and practice of yoga. Participants will not only learn about yoga but also experience it first-hand through stretching and practice. NIH grantees as well as other local and international speakers will explore yoga practice for health. For a schedule of events and additional information visit: does.ors.od.nih.gov/fitness/yogaWeek.htm.

Women's Health Week is May 11–17, 2008

NCCAM provides resources and information on some health issues that affect women, such as menopause, osteoarthritis, and urinary tract infections. We also highlight some of the clinical trials related to women's health issues. Decisions about medical care and treatment should be made in consultation with a health care provider and based on the condition and needs of each person. Discuss information on complementary and alternative medicine (CAM) with your health care provider before making any decisions about treatment or care. Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Director's Testimony: Fiscal Year 2009 Budget Request

I am pleased to present the President's Fiscal Year (FY) budget request for the National Center for Complementary and Alternative Medicine (NCCAM) of the National Institutes of Health. The FY 2009 budget includes $121,695,000, which is $118,000 more than the comparable FY 2008 appropriation of $121,577,000. The public's concept of health is broader than preventing and treating disease. Increasingly, Americans are using strategies that they can employ themselves to improve their health, maintain wellness, and improve quality of life. As part of this participatory approach to health, millions of people are using complementary and alternative medicine (CAM). Many of the leading U.S. medical institutions now offer integrative medicine services. These programs include personalized CAM interventions such as yoga, meditation, massage, and acupuncture. However, we know relatively little about the true potential of CAM to improve health and well being or to preempt disease, or about how best to use most CAM modalities. We also need to understand how CAM practices interact with other therapies and whether they are safe. Given this consumer-driven call for better approaches to improved health and wellness, the medical research community has begun to explore promising CAM approaches and develop the scientific evidence base for CAM modalities that can be integrated as part of comprehensive health care. Using proven scientific methods and rigorous standards, NCCAM is building the research enterprise and the evidence base to better understand CAM. Through scientific investigation, research training programs, and outreach activities, NCCAM's efforts will support the rational integration of proven CAM approaches with conventional medicine.

The Use of Magnets for Pain

Magnets have been used for health purposes for centuries. Static, or permanent, magnets are widely marketed for pain control and are considered part of complementary and alternative medicine. This fact sheet provides an overview of static magnets and summarizes current scientific knowledge about their effects on pain.

Herbal Science International, Inc. Recalls Twelve Dietary Herbal Supplements Nationwide Because of Possible Health Risk Associated with Ephedra, Aristolochic Acid and Human Placenta

FDA has long regarded dietary supplements containing ephedra as potential health hazards because this botanical contains ephedrine alkaloids. Ephedrine alkaloids are adrenaline-like stimulants that can have potentially dangerous effects on the heart. Recent studies have confirmed that ephedrine alkaloids raise blood pressure and otherwise stress the circulatory system, effects that are linked to adverse health effects like heart attacks and strokes. Based on this and other evidence in the scientific literature, FDA issued a rule in February 2004 prohibiting the sale of dietary supplements containing ephedrine alkaloids because they present an unreasonable risk of illness or injury. The company is recalling nine products that contain ephedra, a source of ephedrine alkaloids.

CAM at the NIH - April 2008

NCCAM has a new director, Josephine L. Briggs, M.D. Meet this accomplished researcher and physician, and hear her foremost goal for the upcoming months. It's been 10 years since a groundbreaking NIH conference on acupuncture. What has happened in acupuncture research since then? Where should the field go from here? A recent conference explored these questions. The last thing people need when they are under stress is to get a cold--yet that's what often happens. Is there a scientific connection? A member of NCCAM's Advisory Council talks about some of his work in this area.

Study Sheds Light on the Placebo Effect of Medical Encounters

Researchers have found that a medical encounter may produce its own placebo effects that can bring about significant symptom improvement. The part of the encounter that plays the greatest role in the placebo effect appears to be the physician-patient relationship. In theory, the placebo effect of a medical encounter can be divided into the response to three main components: 1) the assessment and observation, 2) placebo treatment, and 3) patient-physician relationship. This study verified this theory and examined these components of the placebo effect.

Brain Awareness Week is March 10-16, 2008

Brain Awareness Week is an international effort to advance public awareness about the progress and benefits of brain research. The National Center for Complementary and Alternative Medicine is actively involved in brain research, including research on mind-body medicine. Innovative use of imaging technology allows researchers to study the effects of specific CAM therapies on the brain. You can find out more about NCCAM's brain research efforts here.

Pilot Study Provides New Insight on Effect of Ginkgo Extract on Dementia in the Elderly

Overall, in a pilot study of a ginkgo biloba extract for delaying the onset of dementia in the elderly, researchers did not find a reduction in progression to dementia in those using ginkgo versus those using placebo. However, when the researchers took into account participants' adherence to taking the compound, the group that took ginkgo did appear to have a reduced risk of progression and a smaller decline in memory.

Acupuncture Shows Promise in Improving Rates of Pregnancy Following IVF

A review of seven clinical trials of acupuncture given with embryo transfer in women undergoing in vitro fertilization (IVF) suggests that acupuncture may improve rates of pregnancy. An estimated 10 to 15 percent of couples experience reproductive difficulty and seek specialist fertility treatments, such as IVF.

February Is American Heart Month

Heart disease is the leading cause of death in the United States and is a major cause of disability. NCCAM has funded many basic and clinical studies related to heart disease. To ensure safe and coordinated care, people should talk to their health care providers about any CAM therapy that they are currently using or considering.

St. John's Wort and Depression

This fact sheet answers some frequently asked questions about St. John's wort and depression, and summarizes what the science says about its effectiveness and the research being done.

Introduction to Acupuncture

This Backgrounder will provide an introduction to acupuncture as well as resources for more information. Acupuncture is among the oldest healing practices in the world. As part of traditional Chinese medicine (TCM), acupuncture aims to restore and maintain health through the stimulation of specific points on the body.

NCCAM's Advisory Council Welcomes Six New Members

The National Center for Complementary and Alternative Medicine (NCCAM) welcomes six new members to the National Advisory Council for Complementary and Alternative Medicine. The Council serves as the principal advisory body to NCCAM, the lead Federal agency for complementary and alternative medicine research and a component of the National Institutes of Health.

Menopausal Symptoms and CAM

This fact sheet will provide information on menopausal symptoms and complementary and alternative medicine (CAM) based on findings from a 2005 National Institutes of Health State-of-the-Science conference on the management of menopause-related symptoms, as well as resources for more information.

Introduction to Chiropractic

This fact sheet provides basic information about the Chiropractic health care approach that focuses on the relationship between the body's structure-mainly the spine-and its functioning.

FY 2007 Research Awards

The posted table lists research and training grants funded for both new and ongoing research by the National Center for Complementary and Alternative Medicine during Fiscal Year 2007. The list includes the grant number, project title (linked to abstracts on CRISP), principal investigator, institution, and state.

Josephine Briggs, M.D., Named Director of NCCAM

National Institutes of Health (NIH) Director, Elias A. Zerhouni, M.D., today named Josephine P. Briggs, M.D., to be the director of the National Center for Complementary and Alternative Medicine (NCCAM). An accomplished researcher and physician, Dr. Briggs brings a focus on translational research to the study of complementary and alternative medicine (CAM) to help build a fuller understanding of the usefulness and safety of CAM practices.

NCCAM Grantsmanship Workshop

The National Center for Complementary and Alternative Medicine (NCCAM), a component of the National Institutes of Health (NIH), will conduct a 3-day grantsmanship workshop. This workshop will provide researchers, fellows, and graduate students with an in-depth understanding of the NIH grants and review processes, clarify Federal regulations and policies, and highlight areas of special interest and concern. Emphasis will be placed on complementary and alternative medicine (CAM) research. The workshop will include time to interact and discuss research ideas with NCCAM staff. Due to limited space, attendees will be selected through an application process.

CAM at the NIH - Fall 2007

International Team Studies South African Plant for HIV/AIDS Could a plant that is unique to South Africa, and used as a traditional medicine there, be helpful to people with HIV/AIDS? A research team on two continents is working to find out. Also Featuring: Meet NACCAM Member Carlo Calabrese, M.D., M.P.H.; Low Back Pain: NACCAM Symposium; First Transagency Fellow in Cancer CAM

Job Opening: Health Scientist Administrator NCCAM

If you are an exceptionally talented, knowledgeable and motivated individual with excellent knowledge of NIH training and career development programs; have scientific expertise in basic or clinical research that you wish to apply toward advancing the mission of the National Center for Complementary and Alternative Medicine (NCCAM), and ability to work as a member of and provide leadership for a team, within and across groups and organizations, AND you want to play a significant role in a dynamic organization, then consider joining NCCAM's Division of Extramural Research! The Division develops and oversees NCCAM-funded research and research training programs conducted across the country and around the world. The deadline for applications is Friday, January 11, 2008.

Grant Application Notice: NIH Reduces Error Correction Window to Two Business Days

After January 8, the "error correction window" for NIH eSubmission will be the two business days (Mon.–Fri., excluding Federal holidays) that follow the receipt deadline of the Funding Opportunity Announcement.

December 1 Is World AIDS Day

Many people infected with HIV or living with AIDS may be considering the use of complementary and alternative medicine (CAM) to boost their immune system; treat complications of disease; or cope with side effects of conventional medications. This information may be of interest.

Recall of 'True Man Sexual Energy,' 'Energy Max' Dietary Supplements: FDA Press Release

The U.S. Food and Drug Administration requested a recall of True Man Sexual Energy Nutrient Capsules and Energy Max Energy Supplement Men's Formula Capsules, illegal drug products that contain potentially harmful, undeclared ingredients.

New Herbs at a Glance: Noni

This fact sheet provides basic information about noni—common names, uses, potential side effects, and resources for more information. Noni is an evergreen shrub or small tree that grows throughout the tropical regions of the Pacific Ocean, from Southeast Asia to Australia and especially in Polynesia.

New Herbs at a Glance: Soy

This fact sheet provides basic information about soy—uses, potential side effects, and resources for more information. Soy, a plant in the pea family, has been common in Asian diets for thousands of years. It is found in modern American diets as a food or food additive. Soybeans, the high-protein seeds of the soy plant, contain isoflavones-compounds similar to the female hormone estrogen. This fact sheet highlights what is known about soy when used by adults for health purposes.

New Herbs at a Glance: Thunder God Vine

This fact sheet provides basic information about the herb thunder god vine—common names, uses, potential side effects, and resources for more information. Thunder god vine has been used in China for health purposes for more than 400 years.

November Is American Diabetes Month

Nearly 21 million adults and children in the United States are living with diabetes. Some people with diabetes may be considering the use of complementary and alternative medicine (CAM) to either treat their diabetes or its complications. This information may be of interest.

NCCAM Education Grant Program Focus of Academic Medicine Journal Issue

With millions of Americans including complementary and alternative medicine (CAM) in their health care, and as CAM therapies become increasingly available as a result of consumer demand, it is critical that conventional health care professionals be familiar with the most commonly used forms of CAM. The October 2007 issue of the journal Academic Medicine, published by the American Association of Medical Colleges, highlights the results of 15 Education Project Grants funded by NCCAM.

NCCAM Image Gallery

The Image Gallery contains high quality digital photographs available from the National Center for Complementary and Alternative Medicine (NCCAM).

October is National Breast Cancer Awareness Month

While there are no proven CAM treatments for cancer, CAM may be useful to relieve the side effects of treatment and to improve quality of life. NCCAM has a number of resources available for breast cancer patients considering complementary and alternative medicine (CAM).Please visit our site to learn more.

New Herbs at a Glance: Hoodia

Hoodia is a flowering, cactus-like plant native to the Kalahari Desert in southern Africa. Today, hoodia is marketed as an appetite suppressant for weight loss. This fact sheet provides basic information about the herb hoodia—common names, uses, potential side effects, and resources for more information.

New Herbs at a Glance: European Elder

Today, elderberry and elder flower are used for flu, colds, fevers, constipation, and sinus infections. This fact sheet provides basic information about European elder—common names, uses, potential side effects, and resources for more information.

New Herbs at a Glance: Chamomile

Two types of chamomile are used for health conditions: German chamomile and Roman chamomile. This fact sheet provides basic information about the herb chamomile—common names, uses, potential side effects, and resources for more information.

New Herbs at a Glance: Bitter Orange

The bitter orange tree is native to eastern Africa and tropical Asia. Today, it is grown throughout the Mediterranean region and elsewhere, including California and Florida. Bitter orange oil is used in foods, cosmetics, and aromatherapyA therapy in which the scent of essential oils from flowers, herbs, and trees is inhaled to promote health and well-being. products. This fact sheet provides basic information about bitter orange—common names, uses, potential side effects, and resources for more information.

Warning of Red Yeast Rice Products for High Cholesterol

The FDA is warning consumers not to buy or eat three red yeast rice products promoted and sold on Web sites.

FY 2008 Budget Request

On June 22, Ruth L. Kirschstein, M.D., Acting Director NCCAM, presented the President's Fiscal Year (FY) 2008 budget request of $121,699,000 for the National Center for Complementary and Alternative Medicine NCCAM) to the Senate Subcommittee on Labor-HHS-Education Appropriations.

FDA Issues Dietary Supplements Final Rule

The U.S. Food and Drug Administration today announced a final rule establishing regulations to require current good manufacturing practices (cGMP) for dietary supplements. The rule ensures that dietary supplements are produced in a quality manner, do not contain contaminants or impurities, and are accurately labeled. "This rule helps to ensure the quality of dietary supplements so that consumers can be confident that the products they purchase contain what is on the label," said Commissioner of Food and Drugs Andrew C. von Eschenbach, M.D. "In addition, as a result of recent amendments to the Federal Food, Drug, and Cosmetic Act, by the end of the year, industry will be required to report all serious dietary supplement related adverse events to FDA."

CAM Use in Children

Complementary and alternative medicine (CAM) is a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine. As with adults, a wide range of CAM therapies are used in children, including herbs and dietary supplements, massage, acupuncture, chiropractic care, naturopathy, and homeopathy. This fact sheet includes issues to consider and resources for more information when making decisions about CAM use and children.

New Herbs at a Glance: Astragalus

Native to China, astragalus has been used for centuries in traditional Chinese medicine. In the United States, the herb gained popularity in the 1980s. This fact sheet provides basic information about the herb's common names, uses, potential side effects, and resources for more information.

CAM at the NIH: Focus on Complementary and Alternative Medicine

NCCAM's Centers of Excellence: Focusing on the Big—and (Very) Small—PictureWhat do Chinese herbal formulas, mindfulness meditation, electromagnetic beams, and the supplements alpha-lipoic acid and gamma tocopherol have in common? They are among CAM treatments being studied in depth at eight NCCAM-supported research centers.In Memoriam: Stephen E. Straus, M.D.Stephen E. Straus, M.D., founding Director of the National Center for Complementary and Alternative Medicine (NCCAM), died of brain cancer on May 14, 2007. He was 60.

In Memoriam: Stephen E. Straus, M.D., First Director of NIH's National Center for Complementary and Alternative Medicine and Internationally Recognized Physician-Scientist

Stephen E. Straus, M.D., 60, the first director of the National Center for Complementary and Alternative Medicine (NCCAM) at the National Institutes of Health (NIH), died of brain cancer May 14, 2007, at his home in Potomac, Maryland."As NCCAM's first Director, Dr. Straus articulated an uncompromising and compelling agenda for scientific research and research training that engendered broad interest and collaboration," noted Elias A. Zerhouni, M.D., Director of the National Institutes of Health. "His success stemmed from the fact that he understood that the commitment to help patients had to be constantly evolving in order to meet their needs. The NIH has lost a great leader and an outstanding scientist. Most of all, we have lost a dear friend."

Integrative Medicine Consult Service Established at the NIH Clinical Center

The National Center for Complementary and Alternative Medicine (NCCAM) has established an Integrative Medicine Consult Service at the National Institutes of Health (NIH) Clinical Center, the world's largest hospital devoted to research. This service will provide physicians, nurses, and other members of the Clinical Center health care team the ability to discuss complementary and alternative medicine (CAM) therapies with knowledgeable medical staff from the consult service and learn how various CAM practices might complement or interact with a patient's care as a research participant at the Clinical Center.

May is National High Blood Pressure Education Month

Nearly 1 in 3 American adults has high blood pressure, or hypertension. If it is not found and treated, the condition can cause major health problems such as stroke, heart disease, eye problems, or kidney failure. Your doctor can tell you how to prevent and control high blood pressure. NCCAM is studying complementary and alternative medicine (CAM) for this condition—such as mindfulness-based stress reduction. Be sure to tell your doctor about any CAM therapies you are considering, including herbal or dietary supplements. Ask your health care providers about its safety, effectiveness, and possible interactions with medications (both prescription and nonprescription).

An Introduction to Naturopathy

Naturopathy, also called naturopathic medicine, is a whole medical system—one of the systems of healing and beliefs that have evolved over time in different cultures and parts of the world. Naturopathy is rooted in health care approaches that were popular in Europe, especially in Germany, in the 19th century, but it also includes therapies (both ancient and modern) from other traditions. In naturopathy, the emphasis is on supporting health rather than combating disease.

April is Irritable Bowel Syndrome Awareness Month

As many as 20 percent of the adult population, or one in five Americans, has symptoms of irritable bowel syndrome (IBS), making it one of the most common disorders diagnosed by doctors. In an effort to bring attention to the symptoms and difficulties associated with the disorder, April has been designated as IBS Awareness Month. The National Center for Complementary and Alternative Medicine conducts and supports research on many types of diseases and disorders, including IBS. Researchers are studying the effects of acupuncture and the placebo effect on pain caused by IBS. The results have not been published yet.

Grape Seed Extract: Herbs at a Glance

This fact sheet provides basic information about grape seed extract—uses, potential side effects, and resources for more information. The grape seeds used to produce this extract are generally obtained from wine manufacturers.

Lavender: Herbs at a Glance

This fact sheet provides basic information about the herb lavender—common names, uses, potential side effects, and resources for more information. Lavender is native to the Mediterranean region. It was used in ancient Egypt as part of the process for mummifying bodies. Lavender's use as a bath additive originated in Persia, Greece, and Rome. The herb's name comes from the Latin lavare, which means "to wash."

Study compares year-long effectiveness of four weight-loss plans

The very low carbohydrate diet known as the Atkins diet may contribute to greater weight loss than higher carbohydrate plans without negative effects such as increased cholesterol. Christopher Gardner, Ph.D., and colleagues at Stanford University conducted an NCCAM-funded study of 311 pre-menopausal women, all of whom were overweight or obese. Each woman was randomly assigned to one of four diets.

Brain Awareness Week (March 12-18, 2007)

Brain Awareness Week is an international effort to advance public awareness about the progress and benefits of brain research.

Turmeric: Herbs at a Glance

This fact sheet provides basic information about the herb turmeric—common names, uses, potential side effects, and resources for more information. Turmeric, a shrub related to ginger, is grown throughout India, other parts of Asia, and Africa. Known for its warm, bitter taste and golden color, turmeric is commonly used in fabric dyes and foods such as curry powders, mustards, and cheeses. It should not be confused with Javanese turmeric.

Peppermint Oil: Herbs at a Glance

This fact sheet provides basic information about peppermint oil—uses, potential side effects, and resources for more information. The herb peppermint, a cross between two types of mint (water mint and spearmint), grows throughout Europe and North America. Peppermint is often used to flavor foods, and the leaves can be used fresh or dried in teas.

Fenugreek: Herbs at a Glance

This fact sheet provides basic information about the herb fenugreek—common names, uses, potential side effects, and resources for more information. The first recorded use of fenugreek is described on an ancient Egyptian papyrus dated to 1500 B.C. Fenugreek seed is commonly used in cooking.

Job Opening: Director, Office of Policy, Planning, and Evaluation, NCCAM

This position is located in the Office of Policy, Planning and Evaluation (OPPE), National Center for Complementary and Alternative Medicine (NCCAM). NCCAM is dedicated to exploring complementary and alternative healing practices in the context of rigorous science, training complementary and alternative medicine researchers, and disseminating authoritative information to the public and professionals. OPPE is responsible for the science policy, programmatic analyses, program planning, and legislative liaison activities of the Center.

Job Opening: Director of NCCAM

There is much to be done to understand the safety and efficacy of the myriad of CAM therapies used by Americans each year. The NCCAM Director is the leader of the Nation's primary organization for exploring complementary and alternative medicine (CAM) practices in the context of rigorous science, training CAM researchers, and disseminating information to the public and professionals. The incumbent will have the opportunity to build upon a foundation of research that encompasses basic to clinical studies; to attract leading researchers from academic medicine to bring state of the art approaches to studying CAM; and to build a research infrastructure within the CAM community. The incumbent will chart a course for the future of CAM research that will, ultimately, facilitate the integration of proven CAM approaches with conventional health care.

Winter CAM at the NIH Newsletter

Feature stories: Survey: Older Americans' Discussion of CAM with Doctors Findings from a new survey, conducted by AARP in collaboration with NCCAM, on older Americans' use of CAM and their discussions of CAM with their physicians. Thinking About CAM Therapies for Young People Can CAM therapies be helpful to children? Are they safe? Here are some general points to consider in addressing these questions.

Yohimbe: Herbs at a Glance

This fact sheet provides basic information about the herb yohimbe—common names, uses, potential side effects, and resources for more information. The yohimbe tree is a tall evergreen that is native to western Africa. The bark of the tree contains a chemical called yohimbine. The amount of yohimbine in dietary supplements may vary; some yohimbe products have been found to contain very little yohimbine. However, a standardized form of yohimbine—yohimbine hydrochloride—is available as a prescription medicine that has been studied and used for the treatment of erectile dysfunction.

February is American Heart Month

NCCAM is involved in research related to heart health…Clinical TrialsChelation Therapy Study—A large national study of an alternative treatment— chelation therapy and vitamin therapy—for people with heart diseaseExamples of Recently Published Studies:Transcendental meditation and quality of life of African Americans with congestive heart failure Tea consumption and risk of ventricular arrhythmias among patients hospitalized with acute myocardial infarction

AARP/NCCAM Report on Older Americans

Do Americans age 50 and older discuss the use of complementary and alternative medicine (CAM) with their physicians? In spring 2006, AARP and NCCAM partnered on a survey to help answer this question. The consumer survey found that among the 1,559 adults surveyed age 50+ nearly two out of three reported using some form of CAM, yet only one in three of those who have used CAM said they have discussed it with their physicians.

An Introduction to Probiotics

Probiotics are live microorganisms (in most cases, bacteria) that are similar to beneficial microorganisms found in the human gut. They are also called "friendly bacteria" or "good bacteria." Probiotics are available to consumers mainly in the form of dietary supplements and foods. They can be used as complementary and alternative medicine (CAM)

Self-Hypnosis Beneficial for Women Undergoing Breast Biopsy

An NCCAM-funded trial found that women who used self-hypnosis during a type of core needle breast biopsy experienced anxiety relief and reduced pain when compared with standard care. A large core needle breast biopsy is usually an outpatient procedure that limits the use of anesthetic. Women having this procedure often experience anxiety because of the possibility of a cancer diagnosis in addition to the anxiety that patients typically experience during a medical procedure.

Twenty-Sixth NACCAM Meeting, February 2, 2007

The draft agenda is available for the twenty-sixth NACCAM meeting, scheduled for February 2, 2007. NACCAM is charged with the responsibility of advising, consulting with, and making recommendations to the Director, NCCAM, on matters relating to the research activities and functions of the Center. The role and responsibilities of the council members include secondary review of grant applications in light of NCCAM scientific program priorities and program balance.

New Herbs at a Glance: Aloe Vera, Cat's Claw, Chasteberry, and More.

NCCAM has published eight new Herbs at a Glance fact sheets: Aloe Vera, Cat's Claw, Chasteberry, Ephedra, Evening Primrose Oil, Feverfew, Goldenseal, and Hawthorn. Herbs at a Glance is a series of fact sheets that provides basic information about specific herbs or botanicals—common names, uses, potential side effects, and resources for more information.

Herbal Supplement Fails To Relieve Hot Flashes

The herbal supplement black cohosh, whether used alone or with other botanicals, did not relieve hot flashes in women in the Herbal Alternatives (HALT) for Menopause Study. HALT, co-funded by NCCAM and the National Institute on Aging, did find that women using menopausal hormone therapy received significant relief from their hot flashes and night sweats.

NCCAM-Funded Research for FY 2006

This lists research and training grants funded for both new and ongoing research by the National Center for Complementary and Alternative Medicine during Fiscal Year 2006. The list includes the grant number, project title (linked to abstracts on CRISP), principal investigator, institution, and state.

CAM at the NIH, Fall 2006

Stephen E. Straus, M.D., first Director of the National Center for Complementary and Alternative Medicine (NCCAM), stepped down from his position on November 7, 2006, for health reasons. Dr. Straus plans to continue his scientific work at the National Institutes of Health (NIH) as Senior Advisor to the NIH Director. Tools That Are Transforming Discovery in CAM The National Institutes of Health (NIH) is the nation's medical research agency—making important medical discoveries that improve health and save lives. NIH-supported scientists study ways to prevent disease, as well as the causes, treatments, and cures for common and rare diseases. The National Center for Complementary and Alternative Medicine (NCCAM), as a part of NIH, shares in these goals.

Paying for CAM Treatment

If you are using (or thinking about using) complementary and alternative medicine (CAM), you may have financial questions about paying for treatment. This fact sheet answers some frequently asked questions on this topic.

Stephen E. Straus, M.D., Becomes Senior Advisor to NIH Director

On November 7, 2006, Stephen E. Straus M.D., Director of the National Center for Complementary and Alternative Medicine (NCCAM), stepped down from his leadership of the Center for health reasons. Straus will become Senior Advisor to National Institutes of Health (NIH) Director Elias A. Zerhouni, M.D.

NCCAM and The Bernard Osher Foundation Announce New Career Development Award

The National Center for Complementary and Alternative Medicine (NCCAM) today announced a prestigious career development award designed to diminish the barriers that prevent complementary and alternative medicine (CAM) clinicians from exploring a career in research. NCCAM, a part of the National Institutes of Health (NIH), created this award in partnership with The Bernard Osher Foundation through a grant to the Foundation for the National Institutes of Health.

Developing Probiotics as Foods and Drugs

This workshop will review the state of the science supporting clinical applications of probiotics in promoting and sustaining health and in the management of disease conditions. It will also explore how the current regulatory status of probiotics, which are marketed mostly as foods and dietary supplements in the United States, impacts the clinical evaluation of probiotics. Limitations and gaps in the current body of evidence, as well as scientific and regulatory hurdles, will be identified and recommendations will be provided regarding areas in need of future support. NIH is one of the cosponsors of the workshop.

Natural Products: Challenges and Opportunities, Distinguished Lectures

Ram Sasisekharan, Ph.D.Professor of Biological EngineeringMassachusetts Institute of TechnologyOctober 25, 2006 at 11 a.m.Complex carbohydrates called glycans coat the surface of every cell in our bodies, but only recently have scientists been able to probe the structure of these compounds to understand their biological function and how they might be used to prevent or arrest disease. Dr. Ram Sasisekharan and his multidisciplinary team of researchers at MIT have developed a technique for rapidly sequencing these glycans, revealing their structure for the first time. They have discovered that glycans play a key role in the communications between cells that cause cells to divide, migrate and die. Dr. Sasisekharan and his team are pursuing ways to use glycans for diagnostic purposes and to develop alternative carbohydrate-based therapies for a variety of diseases including cancer. Ginseng, heparin and chondroitin have been the focus of recent studies. Please plan to attend and learn more about this new and promising area of research.

Significant Advances in Dietary Supplement Research Released in Annual Bibliography (2005)

The Office of Dietary Supplements at the National Institutes of Health announces the release of the 2005 issue of the Annual Bibliography of Significant Advances in Dietary Supplement Research. This seventh issue of the Bibliography includes abstracts of 25 noteworthy dietary supplement research papers published in 2005, as judged by an international team of reviewers.

Over 1.6 million Americans Use CAM for Insomnia or Trouble Sleeping

A recent analysis of national survey data reveals that over 1.6 million American adults use some form of complementary and alternative medicine (CAM) to treat insomnia or trouble sleeping according to scientists at the National Center for Complementary and Alternative Medicine (NCCAM), part of the National Institutes of Health. The data came from the 2002 National Health Interview Survey (NHIS) conducted by the National Center for Health Statistics of the Centers for Disease Control and Prevention.

Massage Therapy as CAM

Massage therapy is a practice that dates back thousands of years. There are many types of massage therapy; all involve manipulating the muscles and other soft tissues of the body. In the United States, massage therapy is sometimes part of conventional medicine

CAM at the NIH, Summer 2006

International Research Conference Highlights Progress, New DirectionsIn May, more than 600 people from 22 countries gathered at the 2006 North American Research Conference on Complementary and Integrative Medicine. Read about the research findings and perspectives shared on the rich diversity of CAM and integrative medicine. Getting To Know "Friendly Bacteria"Probiotics, also known as "friendly bacteria" or "good bacteria," are found in certain foods and supplements. Find out more about these products and the evidence on their health benefits.

Advisory Council Meeting, September 8

The public is welcome to attend the open session of the upcoming meeting of the National Advisory Council for Complementary and Alternative Medicine (NACCAM). The meeting will be held in Rockville, Maryland on September 8, 2006

Job Opening: International Health Program Specialist, GS 12/13

International Health Program Specialist-NCCAM Deadline: August 22, 2006

Red Clover: Herbs at a Glance

This fact sheet provides basic information about the herb red clover—common names, uses, potential side effects, and resources for more information. Like peas and beans, red clover belongs to the family of plants called legumes. Red clover contains phytoestrogens—compounds similar to the female hormone estrogen.

Licorice Root: Herbs at a Glance

This fact sheet provides basic information about licorice root—common names, uses, potential side effects, and resources for more information. Most licorice is grown in Greece, Turkey, and Asia. Licorice contains a compound called glycyrrhizin (or glycyrrhizic acid). Licorice root has been used as a dietary supplement for stomach ulcers, bronchitis, and sore throat, as well as infections caused by viruses, such as hepatitis.

FDA Warns Consumers and Health Care Providers Not to Use Bismacine, also known as Chromacine

The U.S. Food & Drug Administration (FDA) is warning consumers and health care providers not to use a product called "bismacine," also known as chromacine. The FDA is investigating one report of a death and several reports of injury related to the administration of bismacine.

FDA Warning: Dietary Supplements Used for Sexual Enhancement

FDA Warns Consumers About Dangerous Ingredients in "Dietary Supplements" Promoted for Sexual Enhancement The U.S. Food and Drug Administration (FDA) is warning consumers not to purchase or consume Zimaxx, Libidus, Neophase, Nasutra, Vigor-25, Actra-Rx, or 4EVERON. These products are promoted and sold on web sites as "dietary supplements" for treating erectile dysfunction (ED) and enhancing sexual performance, but they are in fact illegal drugs that contain potentially harmful undeclared ingredients. These products have not been approved by FDA, and there is no guarantee of their safety and effectiveness, or of the purity of their ingredients. FDA advises consumers who have used any of these products to discontinue use and to consult their health care provider. FDA encourages anyone experiencing ED to seek guidance from a health care provider before purchasing a product to treat this medical condition. "These products threaten the public health because they contain undeclared chemicals that are similar or identical to the active ingredients used in several FDA-approved prescription drug products. This risk is even more serious because consumers may not know that these ingredients can interact with medications and dangerously lower their blood pressure," said Dr. Steven Galson, Director of FDA's Center for Drug Evaluation and Research.

New SF424 and PHS 398 Electronic Forms

NOT-OD-06-078 : Grants.gov and NIH/AHRQ recently have made changes to the standard SF424 (R&R) and agency-specific PHS 398 electronic form components used for the electronic submission of grant applications. The forms changes provide greater consistency between forms and align the forms with current policy.

Spring Issue: CAM at the NIH Newsletter

Glucosamine and Chondroitin Sulfate Study Results Announced Glucosamine and chondroitin sulfate are two popular CAM therapies for arthritis. Read about the results of one of NCCAM's largest studies, on the use of these supplements to treat the pain of knee osteoarthritis. The Irresistible Treat That Might Help Resistance Many people enjoy dark chocolate for its taste. Could it have health benefits, too, for insulin resistance—a silent condition that increases one's chances of developing diabetes and heart disease?

DCRC Applicants Conference Call

NCCAM will hold a conference call on Thursday, July 6, 2006, from 2 to 3 pm ET to clarify issues specific to multi-PI applications submitted in response to the Developmental Centers for Research on CAM (DCRC) initiatives. During the call, NCCAM staff will review relevant forms and issues and answer applicants' questions. Please register for the call by sending an e-mail to nccamdcrcinfo@mail.nih.gov. We will send you a call-in phone number and passcode to confirm.

Miller Named Director of Office of Policy, Planning, and Evaluation

Heather G. Miller, Ph.D., M.F.S., was selected as Director for the Office of Policy, Planning, and Evaluation within the National Center for Complementary and Alternative Medicine (NCCAM), at the National Institutes of Health (NIH). Dr. Miller will serve as senior advisor to NCCAM's director on science, science policy, and other strategic issues, as well as oversee the planning, evaluation, and reporting activities for the Center.

Five New Members on the Advisory Council

The National Center for Complementary and Alternative Medicine (NCCAM) welcomes five new members to the National Advisory Council for Complementary and Alternative Medicine (NACCAM). The Council serves as the principal advisory body to NCCAM, a component of the National Institutes of Health within the Department of Health and Human Services. The Council, which meets three times a year, is composed of physicians, scientists, licensed alternative and complementary medicine practitioners, and representatives of the public who contribute their time and expertise over a 4-year term. Council members offer advice and recommendations on the prioritization, conduct, and support of complementary and alternative medicine research, including research training and disseminating health information derived from NCCAM's research.

Job Opening: Scientific Director/Clinical Director

The National Center for Complementary and Alternative Medicine (NCCAM) seeks an accomplished, innovative neuroscientist and clinician to fill three pivotal roles: as Scientific Director and Clinical Director of its Intramural Research Program (IRP) and as Senior Investigator responsible for developing a new research program in mind-body medicine. This individual will report to the NCCAM Director and will be a member of the NCCAM leadership.

Job Opening: Grants Management Specialist

The National Center for Complementary and Alternative Medicine is seeking a Senior Grants Management specialist to serve as a resource to staff associated with grants management related issues. NCCAM is dedicated to exploring complementary and alternative healing practices in the context of rigorous science, training complementary and alternative medicine researchers, and disseminating authoritative information to the public and professionals.

Tai Chi for Health Purposes

Tai chi (pronounced "tie chee" and also known by some other names and spellings) is a mind-body practice that originated in China as a martial art. A person doing tai chi moves his body slowly and gently, while breathing deeply and meditating (tai chi is sometimes called "moving meditation"). Many practitioners believe that tai chi helps the flow throughout the body of a proposed vital energy called qi (pronounced "chee," it means "air," "puff," or "power"). In the United States, tai chi for health purposes is part of complementary and alternative medicine, or CAM. This Backgrounder provides a general overview of tai chi and suggests some resources you can use to find more information.

eCAM: Early Harvest

Second World Ayurveda Congress (Theme: Ayurveda for the Future)--Inaugural Address: Part II

Can Vitex Agnus Castus be Used for the Treatment of Mastalgia? What is the Current Evidence?

There have been many treatments suggested for the management of mastalgia; one of these is the fruit extract of Vitex Agnus castus L. commonly known as Agnus castus, an extract of a deciduous shrub native to Mediterranean Europe and Central Asia. It is postulated that A. castus suppresses the stress-induced latent hyperprolactinemia which is a release of supra-physiological levels of prolactin in some patients in response to stressful stimuli. It is postulated that A. castus could be effective in the treatment of cyclical mastalgia by inhibiting the release of excess prolactin by blocking Dopamine-2 receptor type on pituitary. The adverse events following A. castus treatment are mild and reversible. The aim of this review is assess the efficacy of A. castus in the treatment of mastalgia. Data from randomized and non-randomized studies regarding the efficacy and safety of A. castus is reviewed in a systematic fashion. It is concluded that A. castus can be considered as an efficient alternative phytotherapeutic agent in the treatment of mastalgia.

Mechanism of Reflex Regulation of the Gastroduodenal Function by Acupuncture

Many clinical studies focus on the effects of acupuncture on digestive disorders. However, few studies describe the mechanism by which these effects are produced. We present some recent experimental work on the mechanism of acupuncture for reflex regulation of gastroduodenal function in anesthetized rats. In anesthetized rats, it has been proven that acupuncture to the abdomen excites sympathetic nerves via spinal reflexes causing inhibition of motilities while acupuncture of limbs excites vagus nerves via supraspinal reflexes causing an increase in the motilities. It has also been shown that in order to inhibit gastric motilities, acupuncture stimulation of the abdomen must be strong enough to excite group VI fibers of the afferent intercostal nerves. To increase gastric motilities, acupuncture stimulation to hind limbs must be strong enough to excite the high-threshold group III fibers of tibial nerves. It has also been shown that the neural mechanism of duodenal motility stimulation by acupuncture involves the same body regions and intensity of stimulation as that of gastric motilities. Theories regarding the underlying mechanism have proposed somato-autonomic reflexes and responses via endogenous opioids, etc., but without definitive conclusions.

A Possible Mechanism Underlying the Effectiveness of Acupuncture in the Treatment of Drug Addiction

Clinical trials are currently underway to determine the effectiveness of acupuncture in the treatment of drug addiction. While there are still many unanswered questions about the basic mechanisms of acupuncture, some evidence exists to suggest that acupuncture can play an important role in reducing reinforcing effects of abused drugs. The purpose of this article is to critically review these data. The neurochemical and behavioral evidence showed that acupuncture's role in suppressing the reinforcing effects of abused drugs takes place by modulating mesolimbic dopamine neurons. Also, several brain neurotransmitter systems such as serotonin, opioid and amino acids including GABA have been implicated in the modulation of dopamine release by acupuncture. These results provided clear evidence for the biological effects of acupuncture that ultimately may help us to understand how acupuncture can be used to treat abused drugs. Additional research using animal models is of primary importance to understanding the basic mechanism underlying acupuncture's effectiveness in the treatment of drug addiction.

Comparison of Pharmacopuncture, Aquapuncture and Acepromazine for Sedation of Horses

Pharmacopuncture, the injection of subclinical doses of drugs into acupoints reduces drug undesirable side effects, residues in animal consumption products and treatment costs in large animals. Acepromazine (Acp) produces several undesirable effects, such as hypotension. Previous studies with the injection of 1/10 of Acp dose in dog acupoints showed its advantage for sedation, minimizing undesirable effects. Eight horses were randomly submitted to four different treatment protocols according to a Latin Square double-blind design: (i) 0.1 ml kg–1 of saline subcutaneously injected at the cervical region, (ii) 0.1 mg kg–1 of Acp injected subcutaneously at the cervical region, (iii) 0.01 ml kg–1 of saline injected into GV1 acupoint (aquapuncture) and (iv) 0.01 mg kg–1 of Acp injected into GV1 acupoint (pharmacopuncture). Heart rate, respiratory rate, head height and degree of sedation were measured before and at 30, 60 and 90 min after treatments. Signs of sedation were observed in all treated groups at 30 min and only in 1/10Acp-GV1 at 60 min after the treatments. Only the group treated with 0.1 mg kg–1 of Acp s.c. had significantly lower values of head height at 30 min. Respiratory rate tended to reduce in all groups but was significantly lower only in horses treated with 0.1 mg kg–1 of Acp s.c. Heart rate remained unchanged in all groups. Acp-pharmacopuncture on GV1 in horses produced a mild sedation when compared with the conventional dose of Acp. More investigations are necessary to determine the optimal dosage of Acp-pharmacopuncture for sedation in horses.

Entropy-Based Model for Interpreting Life Systems in Traditional Chinese Medicine

Traditional Chinese medicine (TCM) treats qi as the core of the human life systems. Starting with a hypothetical correlation between TCM qi and the entropy theory, we address in this article a holistic model for evaluating and unveiling the rule of TCM life systems. Several new concepts such as acquired life entropy (ALE), acquired life entropy flow (ALEF) and acquired life entropy production (ALEP) are propounded to interpret TCM life systems. Using the entropy theory, mathematical models are established for ALE, ALEF and ALEP, which reflect the evolution of life systems. Some criteria are given on physiological activities and pathological changes of the body in different stages of life. Moreover, a real data-based simulation shows life entropies of the human body with different ages, Cold and Hot constitutions and in different seasons in North China are coincided with the manifestations of qi as well as the life evolution in TCM descriptions. Especially, based on the comparative and quantitative analysis, the entropy-based model can nicely describe the evolution of life entropies in Cold and Hot individuals thereby fitting the Yin–Yang theory in TCM. Thus, this work establishes a novel approach to interpret the fundamental principles in TCM, and provides an alternative understanding for the complex life systems.

Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats

The protective action against oxidative stress of red cabbage (Brassica oleracea) extract was investigated. Diabetes was induced in male Wistar rats using streptozotocin (60 mg/kg body weight). Throughout the experimental period (60 days), diabetic rats exhibited many symptoms including loss of body weight, hyperglycemia, polyuria, polydipsia, renal enlargement and renal dysfunction. Significant increase in malondialdehyde, a lipid peroxidation marker, was observed in diabetic kidney. This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys. Daily oral ingestion (1 g/kg body weight) of B. oleracea extract for 60 days reversed the adverse effect of diabetes in rats. B. oleracea extract lowered blood glucose levels and restored renal function and body weight loss. In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys. In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

Herbex-kid Inhibits Immediate Hypersensitivity Reactions in Mice and Rats

Herbex-kid (HK), a polyherbal formulation was evaluated in various experimental allergic models of Type I hypersensitivity reactions. Compound 48/80 (C 48/80) has been shown to induce rat mesentery mast cell degranulation and HK (1.07, 10.75 and 107.5 mg ml–1) inhibited the mast cell degranulation in a dose dependent manner. HK (1.07, 10.75 and 107.5 mg kg–1; p.o.) showed dose-dependent protection against C 48/80 induced systemic anaphylaxis in male Balb/C mice. In active anaphylaxis model, male Wistar rats orally administered with 10.75 and 107.5 mg kg–1 of HK showed significant (P < 0.01) protection against mast cell degranulation, while in passive anaphylaxis model, only at 107.5 mg kg–1 showed significant (P < 0.01) reduction in mast cell degranulation. HK at all dose levels was able to significantly decrease the time spent in nasal rubbing in Wistar rats sensitized to ovalbumin, while only at 107.5 mg kg–1 it showed significant (P < 0.01) reduction in number of sneezes. In C 48/80-induced skin itch model, all dose levels of HK significantly (P < 0.001) decreased the time spent in itching and the number of itches. HK did not produce any significant inhibition in histamine induced contraction in guinea pig ileum. From the above findings we conclude that the HK possesses antiallergic activity mediated by reducing of the release mediators from mast cells and also by 5-HT antagonism without the involvement of histamine (H1) receptors.

Estrogenic Activities of Fatty Acids and a Sterol Isolated from Royal Jelly

We have previously reported that royal jelly (RJ) from honeybees (Apis mellifera) has weak estrogenic activity mediated by interaction with estrogen receptors that leads to changes in gene expression and cell proliferation. In this study, we isolated four compounds from RJ that exhibit estrogenic activity as evaluated by a ligand-binding assay for the estrogen receptor (ER) β. These compounds were identified as 10-hydroxy-trans-2-decenoic acid, 10-hydroxydecanoic acid, trans-2-decenoic acid and 24-methylenecholesterol. All these compounds inhibited binding of 17β-estradiol to ERβ, although more weakly than diethylstilbestrol or phytoestrogens. However, these compounds had little or no effect on the binding of 17β-estradiol to ER. Expression assays suggested that these compounds activated ER, as evidenced by enhanced transcription of a reporter gene containing an estrogen-responsive element. Treatment of MCF-7 cells with these compounds enhanced their proliferation, but concomitant treatment with tamoxifen blocked this effect. Exposure of immature rats to these compounds by subcutaneous injection induced mild hypertrophy of the luminal epithelium of the uterus, but was not associated with an increase in uterine weight. These findings provide evidence that these compounds contribute to the estrogenic effect of RJ.

Inhibitory Effects of Bangladeshi Medicinal Plant Extracts on Interactions between Transcription Factors and Target DNA Sequences

Several transcription factors (TFs) play crucial roles in governing the expression of different genes involved in the immune response, embryo or cell lineage development, cell apoptosis, cell cycle progression, oncogenesis, repair and fibrosis processes and inflammation. As far as inflammation, TFs playing pivotal roles are nuclear factor kappa B (NF-kB), activator protein (AP-1), signal transducer and activator of transcription (STATs), cAMP response element binding protein (CREB) and GATA-1 factors. All these TFs regulate the expression of pro-inflammatory cytokines and are involved in the pathogenesis of a number of human disorders, particularly those with an inflammatory component. Since several medicinal plants can be employed to produce extracts exhibiting biological effects and because alteration of gene transcription represents a very interesting approach to control the expression of selected genes, this study sought to verify the ability of several extracts derived from Bangladeshi medicinal plants in interfering with molecular interactions between different TFs and specific DNA sequences. We first analyzed the antiproliferative activity of 19 medicinal plants on different human cell lines, including erythroleukemia K562, B lymphoid Raji and T lymphoid Jurkat cell lines. Secondly, we employed the electrophoretic mobility shift assay as a suitable technique for a fast screening of plant extracts altering the binding between NF-kB, AP-1, GATA-1, STAT-3, CREB and the relative target DNA elements.

Chemical Composition and Botanical Origin of Red Propolis, a New Type of Brazilian Propolis

Red propolis is a new type of Brazilian propolis. This material, as well as the secretions of 20 plant species that are often mentioned as its probable botanical source, have been investigated by RP-HPTLC. Phytochemical evidence based on UV-VIS spectra, RP-HPLC and GC-MS, showed Dalbergia ecastophyllum (L.) Taub. to be the main source of red propolis in Alagoas state. The propolis and plant resin showed high relative percentages of the isoflavonoids 3-Hydroxy-8,9-dimethoxypterocarpan and medicarpin. To our knowledge this is the first report of the secretion of a leguminous species being the source of propolis.

Brazilian Propolis: Correlation Between Chemical Composition and Antimicrobial Activity

The chemical composition of ethanol extracts from samples of Brazilian propolis (EEPs) determined by HPLC and their activity against Trypanosoma cruzi, Staphylococcus aureus, Streptococcus pneumoniae, Klebisiella pneumoniae, Candida albicans, Sporothrix schenckii and Paracoccidioides brasiliensis were determined. Based on the predominant botanical origin in the region of samples' collection, the 10 extracts were separated into three groups: A (B. dracunculifolia + Auraucaria spp), B (B. dracunculifolia) and C (Araucaria spp). Analysis by the multiple regression of all the extracts together showed a positive correlation, higher concentrations leading to higher biological effect, of S. aureus with p-coumaric acid (PCUM) and 3-(4-hydroxy-3-(oxo-butenyl)-phenylacrylic acid (DHCA1) and of trypomastigotes of T. cruzi with 3,5-diprenyl-4-hydroxycinnamic acid derivative 4 (DHCA4) and 2,2-dimethyl-6-carboxyethenyl-2H-1-benzopyran (DCBEN). When the same approach was employed for each group, due to the small number of observations, the statistical test gave unreliable results. However, an overall analysis revealed for group A an association of S. aureus with caffeic acid (CAF) and dicaffeoylquinic acid 3 (CAFQ3), of S. pneumoniae with CAFQ3 and monocaffeoylquinic acid 2 (CAFQ2) and of T. cruzi also with CAFQ3. For group B, a higher activity against S. pneumoniae was associated DCBEN and for T. cruzi with CAF. For group C no association was observed between the anitmicrobial effect and any component of the extracts. The present study reinforces the relevance of PCUM and derivatives, especially prenylated ones and also of caffeolyquinic acids, on the biological activity of Brazilian propolis.

Aromatherapy Massage Affects Menopausal Symptoms in Korean Climacteric Women: A Pilot-Controlled Clinical Trial

This study investigated the effects of aromatherapy massage on menopausal symptoms in Korean climacteric women. Kupperman's menopausal index was used to compare an experimental group of 25 climacteric women with a wait-listed control group of 27 climacteric women. Aromatherapy was applied topically to subjects in the experimental group in the form of massage on the abdomen, back and arms using lavender, rose geranium, rose and jasmine in almond and primrose oils once a week for 8 weeks (eight times in total). The experimental group reported a significantly lower total menopausal index than wait-listed controls (P < 0.05). There were also significant intergroup differences in subcategories such as vasomotor, melancholia, arthralgia and myalgia (all P < 0.05). These findings suggest that aromatherapy massage may be an effective treatment of menopausal symptoms such as hot flushes, depression and pain in climacteric women. However, it could not be verified whether the positive effects were from the aromatherapy, the massage or both. Further rigorous studies should be done with more objective measures.

Chondroprotective Potential of Fruit Extracts of Phyllanthus emblica in Osteoarthritis

There is a need for effective nutraceuticals for osteoarthritis care. The fruit of Phyllanthus emblica is used as a powerful rejuvenator in Ayurvedic medicine. This study measured the chondroprotective potential of P. emblica (‘Amalaki’) fruits in vitro. We used aqueous extracts of unprocessed P. emblica fruit powder (powder A), and the powder obtained after hot water extraction and drying of powder A (powder B). Chondroprotection was measured in three different assay systems. First, we tested the effects of both fruit powders on the activities of the enzymes hyaluronidase and collagenase type 2. Second, an in vitro model of cartilage degradation was set-up with explant cultures of articular knee cartilage from osteoarthritis patients. Cartilage damage was assayed by measuring glycosaminoglycan release from explants treated with/without P. emblica fruit powders. Aqueous extracts of both fruit powders significantly inhibited the activities of hyaluronidase and collagenase type 2 in vitro. Third, in the explant model of cartilage matrix damage, extracts of glucosamine sulphate and powder B (0.05 mg/ml) exhibited statistically significant, long-term chondroprotective activity in cartilage explants from 50% of the patients tested. This result is important since glucosamine sulphate is the leading nutraceutical for osteoarthritis. Powder A induced a statistically significant, short-term chondroprotective activity in cartilage explants from all of the patients tested. This is the first study to identify and quantitate new chondroprotective activities of P. emblica fruits. These data provide pilot pre-clinical evidence for the use of P. emblica fruits as a chondroprotective agent in osteoarthritis therapy.

A Randomized Pilot Study of Atractylenolide I on Gastric Cancer Cachexia Patients

We determined the therapeutic efficacy of atractylenolide I (ATR), extracted from largehead atractylodes rhizome, in managing gastric cancer cachexia (GCC), and interpreted its probable pharmacological mechanism via investigating tumor necrosis factor alpha (TNF-), interleukin-1 (IL-1), interleukin-6 (IL-6) and proteolysis-inducing factor (PIF). This was a randomized but not-blinded pilot. The study group (n = 11) received 1.32 g per day of atractylenolide I (ATR) and the control group (n = 11) received 3.6 g per day of fish-oil-enriched nutritional supplementation (FOE) for 7 weeks. Conservative therapy was similar in both groups. Clinical [appetite, body weight, mid-arm muscle circumference (MAMC), Karnofsky performance status (KPS) status], biomarker (TNF-, IL-1, IL-6 and PIF) were evaluated in the basal state, at the third and seventh weeks. To analyze changes of cytokines, an immumohistochemistry technique was adopted. Base line characteristics were similar in both groups. Effects on MAMC and body weight increase, TNF- increase and IL-1 decreases of serum level were significant in both groups (P < 0.05). ATR was significantly more effective than FOE in improving appetite and KPS status, and decreasing PIF positive rate (P < 0.05). Slight nausea (3/11) and dry mouth (1/11) were shown in intervention groups but did not interrupt treatment. These preliminary findings suggest that ATR might be beneficial in alleviating symptoms, in modulating cytokine and in inhibiting PIF proteolysis of gastric cancer cachexia. Further research using a randomized controlled design is necessary to confirm these pilot study findings.

Dominican Children with HIV not Receiving Antiretrovirals: Massage Therapy Influences their Behavior and Development

Forty-eight children (M age = 4.8 years) infected with HIV/AIDS and living in the Dominican Republic were randomly assigned to a massage therapy or a play session control group. The children in the massage therapy group received two weekly 20-min massages for 12 weeks; the children in the control group participated in a play session (coloring, playing with blocks) for the same duration and length as the massage therapy group. Overall, the children in the massage therapy group improved in self-help abilities and communication, suggesting that massage therapy may enhance daily functioning for children with HIV/AIDS. Moreover, the HIV infected children who were six or older also showed a decrease in internalizing behaviors; specifically depressive/anxious behaviors and negative thoughts were reduced. Additionally, baseline assessments revealed IQ equivalence below normal functioning for 70% of the HIV infected children and very high incidences of mood problems (depression, withdrawn) for 40% of the children and anxiety problems for 20% of the children, suggesting the need for better monitoring and alternative interventions in countries with limited resources to improve cognition and the mental health status of children infected with HIV/AIDS.

An Evaluation of the Additive Effect of Natural Herbal Medicine on SARS or SARS-like Infectious Diseases in 2003: A Randomized, Double-blind, and Controlled Pilot Study

Natural herbal medicine (NHM) has been used to control infectious diseases for thousands of years. In view of the possible beneficial effect of NHM on SARS, we conducted this study to examine whether NHM is of any benefit as a supplementary treatment of SARS or SARS-like infectious disease. This was a randomized, double-blind, placebo-controlled trial. Twenty-eight patients fulfilled the WHO inclusion criteria and our exclusion criteria. All enrolled patients received routine western-medicine treatment. Patients were randomly allocated to one of the three supplementary treatment groups: NHM A (Group A, n = 9) NHM B (Group B, n = 9) or placebo (Group C, n = 10). Chest X-ray was done every 1 or 2 days for every patient. Reading radiologists use a standard 0–3 scoring system (0: no infiltration; 1: focal haziness or even small patchy lesion; 2: ground glass picture; 3: lobar consolidation) according to the severity of infiltration in each lung field (three lung fields in both right and left lungs). The main outcome measurements were the improving chest radiographic scores (IRS) and the duration (days) till improvement (DI). One patient from the placebo group passed away. Patients from NHM A took less days before showing improvement (6.7 ± 1.8) compared with placebo group (11.2 ± 4.9), which showed statistical significance (P = 0.04). The cases were too few to be conclusive, the initial observations seem to indicate NHM appears to be safe in non-criticallly ill patients and clinical trials are feasible in the setting of pandemic outbreaks.

Traditional Arabic and Islamic Medicine (TAIM) now joins TCM CAM, Kampo and Ayurveda