Alternative medicine describes practices used in place of conventional medical treatments. Complementary medicine describes alternative medicine used in conjunction with conventional medicine. The term complementary and alternative medicine (CAM) is an umbrella term for both branches. Alternative medicine includes practices that incorporate spiritual, metaphysical, or religious underpinnings; non-European medical traditions or newly developed approaches to healing.

The National Center for Complementary and Alternative Medicine defines complementary and alternative medicine as "a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine". It also defines integrative medicine as "mainstream medical therapies and CAM therapies for which there is some high-quality scientific evidence of safety and effectiveness" . Ralph Snyderman and Andrew Weil state "integrative medicine is not synonymous with complementary and alternative medicine (CAM). It has a far larger meaning and mission in that it calls for restoration of the focus of medicine on health and healing and emphasizes the centrality of the patient-physician relationship" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11863470 PMID 11863470.

Proponents of evidence-based medicine regard the distinction between conventional and alternative medicines as false, preferring "good medicine" with provable efficacy and "bad medicine" without. "Bad medicine" is any treatment where the efficacy and safety of which has not been verified through peer-reviewed, double blind placebo controlled studies, regarded as the "gold standard" for determining the efficacy of a compound. It is thus possible for a method to change categories in either direction, based on increased knowledge of its effectiveness or lack thereof. Richard Dawkins, Professor of the Public Understanding of Science at Oxford, argues that alternative medicine should be defined as that set of practices that cannot be tested, refuse to be tested or consistently fail tests. He also states that "There is no alternative medicine. There is only medicine that works and medicine that doesn't work."

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NCCAM Featured Content

NCCAM's Advisory Council Welcomes Six New Members
Fri, 03 Feb 2012 11:14:14 -0500
The National Center for Complementary and Alternative Medicine (NCCAM) welcomes six new members to the National Advisory Council for Complementary and Alternative Medicine. The council serves as the principal advisory body to NCCAM, the lead federal agency for research on complementary medicine, and a component of the National Institutes of Health.
In the News: Resveratrol
Thu, 02 Feb 2012 12:44:28 -0500
Resveratrol is a naturally occurring chemical found in red wine and other plant products and is sometimes sold as a dietary supplement. Recently, a study funded by the National Heart, Lung, and Blood Institute looked at how resveratrol works at the cellular level, identifying how it may provide its health benefits.
In the News: Placebo Effect
Tue, 10 Jan 2012 17:32:37 -0500
Recently, several news outlets have been highlighting research studies of the placebo effect. The placebo response can be defined as the benefit patients receive from a treatment that has no active components. Researchers are using innovative study designs to untangle the complexities of the placebo effect.

BMC Complementary and Alternative Medicine - Latest Articles

In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract
Natalia Esteves-PedroThaisa BorimVirginia SbrunegaMagali SilvaPatricia SantosMarcio SantosChariston Dal BeloCassia Regina CardosoEliana VarandaFrancisco GropoMarli GerenuttiYoko Oshima-Franco Fri, 03 Feb 2012 00:00:00 -0000
Background: Dipteryx alata Vogel popularly known as "baru" is an important commercial leguminous tree species from the Brazilian Cerrado, which possess medicinal properties, besides its fruits consumption by animals and humans. The use of the "naturally occurring plants" as herbal remedies and foods mainly from leaves, seeds, flowers and roots of plants or extracts require precautions before ensuring these are safe and efficacious. The objective of this study was to evaluate the safety of D. alata barks extract. Methods: Vegetal drugs of D. alata barks were submitted to quality control assays and further to the safety assays under 1) in vitro parameter by Salmonella (Ames) mutagenicity, and 2) in vivo parameter on the pregnancy of rats. Results: The extract was non-mutagenic to any of the assessed strains TA97a, TA98, TA100 and TA102 even after metabolic activation (+S9). All in vivo parameters (reproductive ability evaluation, physical development of rat offsprings, and neurobehavioral development assays) showed no changes related to control group. Conclusion: D. alata barks extract is neither mutagenic by the Ames test nor toxic in the pregnancy of rats, with no physical-neurobehavioral consequences on the rat offsprings development.
Effect of aqueous extract of Arctium lappa L. (burdock) roots on the sexual behavior of male rats
Jian Feng CaoPengYing ZhangChengWei XuTaoTao HuangYun Gui BaiKaoShan Chen Wed, 01 Feb 2012 00:00:00 -0000
Background: Arctium lappa L. root has traditionally been recommended as an aphrodisiac agent. It is used to treat impotence and sterility in China, and Native Americans included the root in herbal preparations for women in labor. However, its use has not been scientifically validated. The present study therefore investigated the effects of aqueous extract of Arctium lappa L. roots on sexual behavior in normal male rats. Methods: Seventy-five albino male rats were randomly divided into five groups of 15 rats each. Rats in group 1 (control) were administered 10 mLkg body weight distilled water (vehicle), group 2 received 60 mg/kg body weight sildenafil citrate (Viagra), while those in groups 3, 4, and 5 were given 300, 600, and 1,200 mg/kg body weight, respectively, of aqueous extract of Arctium lappa L. roots in the same volume. Female albino rats were made receptive by hormonal treatment. Sexual behavior parameters in male rats were monitored on days 3, 7 and 15 by pairing with receptive females (1:3). Male serum testosterone concentrations and potency were also determined. Results: Oral administration of Arctium lappa L. roots extract at 600 and 1,200 mg/kg body weight significantly increased the frequencies of mount, intromission, and ejaculation frequency (p < 0.05). The latencies of mount and intromission were significantly reduced and ejaculation latency was prolonged. Administration of the extract also reduced the post-ejaculatory interval. The standard drug (Viagra) was more effective than the extract. The extract significantly increased the frequencies of all components of penile reflexes as well as serum testosterone levels, compared with the distilled water controls. Conclusions: The results of this study demonstrate that aqueous extract of Arctium lappa L. roots enhances sexual behavior in male rats. The aphrodisiac effects of the plant extract may be related to the presence of flavonoids, saponins, lignans and alkaloids, acting via a multitude of central and peripheral mechanisms. These results thus support the traditional use of Arctium lappa L. root extract for treating impotence and sterility.
Impact of Tai Chi exercise on multiple fracture-related risk factors in post-menopausal osteopenic women: a pilot pragmatic, randomized trial
Peter WayneDouglas KielJulie BuringEllen ConnorsPaolo BonatoGloria YehCalvin CohenChiara MancinelliRoger Davis Mon, 30 Jan 2012 00:00:00 -0000
Background: Tai Chi (TC) is a mind-body exercise that shows potential as an effective and safe intervention for preventing fall-related fractures in the elderly. Few randomized trials have simultaneously evaluated TC's potential to reduce bone loss and improve fall-predictive balance parameters in osteopenic women. Methods: In a pragmatic randomized trial, 86 post-menopausal osteopenic women, aged 45-70, were recruited from community clinics. Women were assigned to either nine months of TC training plus usual care (UC) vs. UC alone. Primary outcomes were changes between baseline and nine months of bone mineral density (BMD) of the proximal femur and lumbar spine (dual-energy X-ray absorptiometry) and serum markers of bone resorption and formation. Secondary outcomes included quality of life. In a subsample (n=16), quiet standing fall-predictive sway parameters and clinical balance tests was also assessed. Both intent-to-treat and per-protocol analyses employed. Results: For BMD, no intent-to-treat analyses were statistically significant; however, per protocol analyses (i.e., only including TC participants who completed [greater than or equal to] 75% training requirements) of femoral neck BMD changes were significantly different between TC and UC (+0.04 vs. -0.98%; P=0.05). Changes in bone formation markers and physical domains of quality of life were also more favorable in per protocol TC vs. UC (P=0.05). Changes in sway parameters were significantly improved by TC vs. UC (average sway velocity, P=0.027; anterior-posterior sway range, P=0.014). Clinical measures of balance and function showed statistically non-significant trends in favor of TC. Conclusions: TC training offered through existing community-based programs is a safe, feasible, and promising intervention for reducing multiple fracture risks. Our results affirm the value of a more definitive, longer-term trial of TC for osteopenic women, adequately powered to detect clinically relevant effects of TC on attenuation of BMD loss and reduction of fall risk in this population.Trail registration: clinicaltrials.gov NCT01039012

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